ClosedResearch announcementOpportunity HT942526ALSRPPCTA

DoW Amyotrophic Lateral Sclerosis Research Program, Pilot Clinical Trial Award

Defense Health Agency Contracting Activity - DHACA · Department of Defense

At a glance

DoW Amyotrophic Lateral Sclerosis Research Program, Pilot Clinical Trial Award is a closed federal grant opportunity from the Defense Health Agency Contracting Activity - DHACA (Department of Defense). The application deadline was September 30, 2026. Total estimated funding is $5.6M across about 2 awards. The notice is unrestricted by applicant type, subject to any clarifications in the notice. Cost sharing is not required. It is funded under Assistance Listing 12.420 (Military Medical Research and Development).

Summary assembled from the official notice's fields. The official notice governs.

Key facts

May 4, 2026Posted
Sep 30, 2026Application deadline
Oct 30, 2026Archivednext date

Posted: May 4, 2026
Close date: Sep 30, 2026
Archive date: Oct 30, 2026
Award floor: Not specified
Award ceiling: Not specified
Est. total funding: $5,600,000
Implied average award: $2,800,000 calculated
Expected awards: 2
Cost sharing: Not required
Funding instrument: Grant
Opportunity category: Discretionary

Typical awards for this program (SAM.gov listing for ALN 12.420, not this notice): This Assistance Listing supports approximately 30 or more programs each year. Overall, awards are expected to range from $100,000 to $20M (consortium) depending on the funding priorities, anticipated number of awards, and project activity/scope within each program for an award period, on average, of 3 to 4 years. The maximum award amount, if any, is specified in each Program Announcement or Broad Agency Announcement.

Implied average = estimated total funding ÷ expected number of awards, calculated by GrantsJunction. Actual awards vary.

Who can apply

Unrestricted (any entity type)

Can your organization apply?

A quick check against the listed applicant types — other requirements in the notice still apply.

Based on the published notice. Review the official notice for complete eligibility requirements.

What it funds

Official synopsis as published by the agency, formatted for readability.

Summary: The fiscal year 2026 (FY26) Amyotrophic Lateral Sclerosis Research Program (ALSRP) Pilot Clinical Trial Award (PCTA) supports the rapid implementation of clinical trials with the potential to have a significant impact on the treatment or management of amyotrophic lateral sclerosis (ALS). Projects may range from phase 1 to small-scale phase 2 trials.

Applications must address one of the following focus areas:

· Biomarker-Driven Interventions: Disease-modifying interventions, with mechanism-specific biomarkers to predict which clinical trial participants are likely to respond, demonstrate target engagement, and effects on the intended biological pathway.

· Clinical Care: Improving aspects of clinical care and symptom management for ALS.

Distinctive Features: Funding from this award mechanism must support a clinical trial. The clinical trial should begin no later than 12 months after the award date or 18 months for U.S. Food and Drug Administration (FDA)-regulated studies.

Projects proposing a therapeutic intervention (drug, biologic, and/or device) must incorporate biomarkers specific to the intervention into the trial design.

All pre-applications and applications are required to incorporate community collaboration, as described in Section 3.2.2, to optimize research impact.

Applications must include a detailed Regulatory Strategy plan that outlines the approach for obtaining regulatory approvals, if required, specifically for the funded portion of the study. In addition, applications must provide a separate Transition Plan that describes how the outcomes of the study will be advanced to the next phase of development, beyond the scope of the funded work.

Full announcement & documents

The full announcement has the complete rules — page limits, required attachments, evaluation criteria and any letter-of-intent dates. Files download directly from Grants.gov.

FY26 ALSRP PCTA Program AnnouncementFull Announcement · HT942526ALSRPPCTA_GG2.pdfPDF · 779 KB

Assistance Listing

What is an ALN?

12.420Military Medical Research and DevelopmentProgram →

Reported obligations under ALN 12.420

Historical data · not a prediction

FY24

$1.48B

FY25

$1.2B

FY26

— est.

Source: SAM.gov Assistance Listing 12.420. Program-wide totals, not awards from this specific opportunity.

Who was funded under ALN 12.420

Historical data · not a prediction

Since October 1, 2023, 6,147 grant awards had funding actions under Military Medical Research and Development, with 2,218 sub-awards passed on to other organizations. These are program-wide awards, not awards from this specific notice.

THE HENRY M. JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE, INC.$139M
THE UNIVERISTY OF TEXAS M.D. ANDERSON CANCER CENTER$118M
REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE$81.8M
THE JOHNS HOPKINS UNIVERSITY$72.4M
UNIVERSITY OF CALIFORNIA, LOS ANGELES$62.2M

Recipients, states, recent awards and sub-awards →Source: USAspending.gov.

Agency contact (as published)

Jamie Shortall Grant Officer
help@eBRAP.org
301-619-2393

Quick answers

Who is eligible to apply for “DoW Amyotrophic Lateral Sclerosis Research Program, Pilot Clinical Trial Award”?

The notice lists eligibility as unrestricted — open to any type of entity — subject to clarifications in the notice's additional eligibility information.

How much funding is available through “DoW Amyotrophic Lateral Sclerosis Research Program, Pilot Clinical Trial Award”?

Per the notice, total estimated program funding is $5,600,000 and the agency expects to make about 2 awards.

How do I apply for “DoW Amyotrophic Lateral Sclerosis Research Program, Pilot Clinical Trial Award”?

Applications are submitted through the official source, not through GrantsJunction. Open the official notice on Grants.gov (opportunity HT942526ALSRPPCTA), and review the full announcement and application package. Organizations applying through Grants.gov generally need an active SAM.gov registration and a Grants.gov account, which can take several weeks to set up.

Matched on shared Assistance Listings, agency, categories and eligible applicant types.

Closes in 6 daysResearchALN 12.420