OpenResearch announcementOpportunity PAR-25-024

Development of Biomarkers or Composite Biomarkers for Neurological and Neuromuscular Disorders (R61/R33 - Clinical Trial Optional)

National Institutes of Health · Department of Health and Human Services

At a glance

Development of Biomarkers or Composite Biomarkers for Neurological and Neuromuscular Disorders (R61/R33 - Clinical Trial Optional) is an open federal grant opportunity from the National Institutes of Health (Department of Health and Human Services). Applications are due January 7, 2028. Applicant types listed as eligible include state governments, county governments, city or township governments, special district governments, independent school districts and 10 more. Cost sharing is not required. It is funded under Assistance Listing 93.853 (Extramural Research Programs in the Neurosciences and Neurological Disorders) and 1 other listing.

Summary assembled from the official notice's fields. The official notice governs.

Key facts

Oct 28, 2024Posted
Jan 7, 2028Application deadlinenext date
Feb 12, 2028Archived

Posted: Oct 28, 2024
Close date: Jan 7, 2028
Archive date: Feb 12, 2028
Award floor: Not specified
Award ceiling: Not specified
Est. total funding: Not specified
Expected awards: Not specified
Cost sharing: Not required
Funding instrument: Grant
Opportunity category: Discretionary

Typical awards for this program (SAM.gov listing for ALN 93.853, not this notice): Research grants: $22,709 to $7,753,905; $585,282. National Research Service Awards: Institutional $34,076 to $692,757; $193,304. Individual: $5,495 to $90,284; $46,239. SBIR/STTR: Phase 1 not to exceed $150,000; Phase II not to exceed $1,000,000; however with appropriate justification, budget caps for Phase I and Phase II are $225,000 and $1,500,00 respectively

Who can apply

State governments
County governments
City or township governments
Special district governments
Independent school districts
Public colleges & universities
Federally recognized tribal governments
Public & Indian housing authorities
Native American tribal organizations
501(c)(3) nonprofits
Nonprofits without 501(c)(3) status
Private colleges & universities
For-profit organizations (not small businesses)
Small businesses
Others (see notice)

Additional information on eligibility (from the notice)

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.

Can your organization apply?

A quick check against the listed applicant types — other requirements in the notice still apply.

Based on the published notice. Review the official notice for complete eligibility requirements.

What it funds

Official synopsis as published by the agency, formatted for readability.

The overarching purpose of this Funding Opportunity Announcement (FOA) is to promote the discovery and/or early evaluation of strong candidate biomarkers and biomarker signatures that can be used as tools to facilitate the clinical development of neurotherapeutics and their use in clinical practice. Specifically, the focus of this FOA is on the identification and initial biological, analytical and clinical evaluation of biomarkers and biomarker signatures for neurological and neuromuscular disorders. Although research supported by this FOA can include animal studies, it must also include preliminary human evaluation using carefully standardized human samples or datasets. The goal of this initiative is to deliver candidate biomarkers or biomarker signatures that are ready for definitive analytical and clinical validation studies.

Additional information from the agency ↗

Full announcement & documents

The full announcement has the complete rules — page limits, required attachments, evaluation criteria and any letter-of-intent dates. Files download directly from Grants.gov.

PAR-25-024 Full Announcement TextFull Announcement · PAR-25-024-Full-Announcement.htmlHTML · 1 KB

How to apply

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Read the full announcement (NOFO)Eligibility, evaluation criteria, page limits and required attachments are in the full notice on Grants.gov. Open ↗
Confirm eligibility and fitCheck your organization type above; no cost sharing is required.
Register (or renew) in SAM.gov and get a UEIFree. New registrations can take several weeks; registrations must be renewed every year. Open ↗
Set up Grants.gov accessCreate a Grants.gov account and make sure someone has the Authorized Organization Representative (AOR) role. Open ↗
Open the application packageUse opportunity number PAR-25-024 on Grants.gov (Grants.gov Workspace). Open ↗
Prepare narrative, budget and attachmentsFollow the notice's format exactly — page limits and required forms are common reasons applications are rejected.
Ask the agency contact any questions earlyNational Institutes of Health · grantsinfo@nih.gov Open ↗
Submit before January 7, 2028Submit a few days early and keep your Grants.gov confirmation and validation emails.

Assistance Listings

What is an ALN?

Reported obligations under ALN 93.853

Historical data · not a prediction

FY24

$2.36B

FY25

$2.35B

FY26

— est.

Source: SAM.gov Assistance Listing 93.853. Program-wide totals, not awards from this specific opportunity.

Who was funded under ALN 93.853

Historical data · not a prediction

Since October 1, 2023, 10,021 grant awards had funding actions under Extramural Research Programs in the Neurosciences and Neurological Disorders, with 5,577 sub-awards passed on to other organizations. These are program-wide awards, not awards from this specific notice.

THE GENERAL HOSPITAL CORPORATION$203M
REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE$173M
THE JOHNS HOPKINS UNIVERSITY$167M
REGENTS OF THE UNIVERSITY OF MICHIGAN$155M
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK$141M

Recipients, states, recent awards and sub-awards →Source: USAspending.gov.

Agency contact (as published)

National Institutes of Health
grantsinfo@nih.gov
301-402-2541

Quick answers

When is the deadline for this opportunity?

According to the official notice, applications are due January 7, 2028. Confirm the deadline and submission time on Grants.gov before applying.

Who is eligible to apply for this opportunity?

The official notice names these applicant types as eligible: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public colleges & universities, Federally recognized tribal governments, Public & Indian housing authorities, Native American tribal organizations, 501(c)(3) nonprofits, Nonprofits without 501(c)(3) status, Private colleges & universities and 3 more. Additional restrictions may apply; review the full notice.

How do I apply for this opportunity?

Applications are submitted through the official source, not through GrantsJunction. Open the official notice on Grants.gov (opportunity PAR-25-024), and review the full announcement and application package. Organizations applying through Grants.gov generally need an active SAM.gov registration and a Grants.gov account, which can take several weeks to set up.

Matched on shared Assistance Listings, agency, categories and eligible applicant types.

ForecastedResearchALN 93.121, 93.213…