ForecastedResearch announcementOpportunity PAR-26-064

Specialized Programs of Research Excellence (SPOREs) in Human Cancers for Years 2027, 2028, and 2029 (P50 Clinical Trial Required)

National Institutes of Health · Department of Health and Human Services

At a glance

Specialized Programs of Research Excellence (SPOREs) in Human Cancers for Years 2027, 2028, and 2029 (P50 Clinical Trial Required) is a forecasted federal grant opportunity from the National Institutes of Health (Department of Health and Human Services). The agency's forecast estimates an application due date of January 25, 2027; forecast dates can change. Total estimated funding is $25M across about 12 awards. Applicant types listed as eligible include state governments, county governments, city or township governments, special district governments, independent school districts and 10 more. Cost sharing is not required. It is funded under Assistance Listing 93.395 (Cancer Treatment Research).

Summary assembled from the official notice's fields. The official notice governs.

Key facts

Sep 9, 2025Forecast posted
Oct 31, 2025 (est.)Full notice expected
Jan 25, 2027 (est.)Application deadlinenext date
Jun 4, 2027 (est.)Est. award date

Posted: Sep 9, 2025
Est. close date: Jan 25, 2027
Est. award date: Jun 4, 2027
Award floor: Not specified
Award ceiling: Not specified
Est. total funding: $25,000,000
Implied average award: $2,083,333 calculated
Expected awards: 12
Cost sharing: Not required
Funding instrument: Grant
Opportunity category: Discretionary
Fiscal year: FY2027

Typical awards for this program (SAM.gov listing for ALN 93.395, not this notice): Range: $5,000 to $22,055,360 Average: $653,665

Implied average = estimated total funding ÷ expected number of awards, calculated by GrantsJunction. Actual awards vary.

Who can apply

State governments
County governments
City or township governments
Special district governments
Independent school districts
Public colleges & universities
Federally recognized tribal governments
Public & Indian housing authorities
Native American tribal organizations
501(c)(3) nonprofits
Nonprofits without 501(c)(3) status
Private colleges & universities
For-profit organizations (not small businesses)
Small businesses
Others (see notice)

Additional information on eligibility (from the notice)

Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;Non-domestic (non-U.S.) Entities (Foreign Institutions).

Can your organization apply?

A quick check against the listed applicant types — other requirements in the notice still apply.

Based on the published notice. Review the official notice for complete eligibility requirements.

What it funds

Official synopsis as published by the agency, formatted for readability.

Through this Notice of Funding Opportunity (NOFO), the National Cancer Institute (NCI) invites applications for P50 Research Center Grants for Specialized Programs of Research Excellence (SPORE). This is a re-issuance of PAR-23-284. The program will fund P50 SPORE grants to support state-of-the-art investigator-initiated translational research that will contribute to improved prevention, early detection, diagnosis, and treatment of an organ-specific cancer or a highly related group of cancers. For the purpose of this NOFO, a group of highly related cancers are those that are derived from the same organ system, such as gastrointestinal, neuroendocrine, head and neck, and other cancers. Other programmatically appropriate groups of cancers may include those centered around a common biological mechanism critical for promoting tumorigenesis and/or cancer progression in organ sites that belong to different organ systems. For example, a SPORE may focus on cancers caused by the same infectious agent or cancers promoted and sustained by dysregulation of a common signaling pathway. In addition, a SPORE may focus on cross-cutting themes such as pediatric cancers or epigenetics. The research supported through this program must be translational and must stem from research on human biology using cellular, molecular, structural, biochemical, and/or genetic experimental approaches. SPORE projects must have the goal of reaching a translational human endpoint within the project period of the grant.

How to apply

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Read the full announcement (NOFO)Eligibility, evaluation criteria, page limits and required attachments are in the full notice on Grants.gov. Open ↗
Confirm eligibility and fitCheck your organization type above; no cost sharing is required.
Register (or renew) in SAM.gov and get a UEIFree. New registrations can take several weeks; registrations must be renewed every year. Open ↗
Set up Grants.gov accessCreate a Grants.gov account and make sure someone has the Authorized Organization Representative (AOR) role. Open ↗
Watch for the full noticeThe agency estimates posting it around October 31, 2025. Save this grant to track changes.
Prepare narrative, budget and attachmentsFollow the notice's format exactly — page limits and required forms are common reasons applications are rejected.
Ask the agency contact any questions earlyBradley T. Scroggins · bradley.scroggins@nih.gov Open ↗
Submit before January 25, 2027Submit a few days early and keep your Grants.gov confirmation and validation emails.

Assistance Listing

What is an ALN?

93.395Cancer Treatment ResearchProgram →

Reported obligations under ALN 93.395

Historical data · not a prediction

FY24

$1.3B

FY25

$1.41B

FY26

$927M est.

Source: SAM.gov Assistance Listing 93.395. Program-wide totals, not awards from this specific opportunity.

Who was funded under ALN 93.395

Historical data · not a prediction

Since October 1, 2023, 4,273 grant awards had funding actions under Cancer Treatment Research, with 2,896 sub-awards passed on to other organizations. These are program-wide awards, not awards from this specific notice.

THE UNIVERISTY OF TEXAS M.D. ANDERSON CANCER CENTER$129M
DANA-FARBER CANCER INSTITUTE, INC.$121M
ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI$116M
FRED HUTCHINSON CANCER CENTER$101M
SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH$91.1M

Recipients, states, recent awards and sub-awards →Source: USAspending.gov.

Agency contact (as published)

Bradley T. Scroggins
bradley.scroggins@nih.gov
240-276-7860

Quick answers

Is this opportunity open for applications yet?

Not yet. It is a forecast — an agency's advance notice of an expected opportunity. The agency estimates posting the full notice around October 31, 2025. Forecast details and dates can change.

Who is eligible to apply for this opportunity?

The official notice names these applicant types as eligible: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public colleges & universities, Federally recognized tribal governments, Public & Indian housing authorities, Native American tribal organizations, 501(c)(3) nonprofits, Nonprofits without 501(c)(3) status, Private colleges & universities and 3 more. Additional restrictions may apply; review the full notice.

How much funding is available through this opportunity?

Per the notice, total estimated program funding is $25,000,000 and the agency expects to make about 12 awards.

How do I apply for this opportunity?

Applications are submitted through the official source, not through GrantsJunction. Open the official notice on Grants.gov (opportunity PAR-26-064), and review the full announcement and application package. Organizations applying through Grants.gov generally need an active SAM.gov registration and a Grants.gov account, which can take several weeks to set up.

Matched on shared Assistance Listings, agency, categories and eligible applicant types.

ForecastedResearchALN 93.393, 93.394…