Biophotonics

Biophotonics applies photonics technology to the fields of medicine, biology and biotechnology. Basic research and innovation in photonics that is very fundamental in science and engineering is needed to lay the foundation for new technologies beyond those that are mature and ready for application in medical diagnostics and therapies. Advances are needed in nanophotonics, optogenetics, contrast and targeting agents, ultra-thin probes, wide field imaging, and rapid biomarker screening. Low cost and minimally invasive medical diagnostics and therapies are key goals.Examples of topics are:Macromolecule Markers - Innovative methods for labeling of macromolecules, new compositions of matter/methods of fabrication of multi-color probes such as might be used for marking and detection of specific pathological cells and push the envelope of optical sensing to the limits of detection, resolution, and identificationLow Coherence Sensing at the Nanoscale - Low coherence enhanced backscattering (LEBS), n-dimensional elastic light scattering, and angle-resolved low coherence interferometry for early cancer detection (dysplasia)Neurophotonics - Studies of photon activation of neurons at the interface of nanomaterials attached to cells. Development and application of biocompatible photonic tools such as parallel interfaces and interconnects for communicating and control of neural networksMicro- and Nano-photonic - Development and application of nanoparticle fluorescent quantum-dots; sensitive, multiplexed, high-throughput characterization of macromolecular properties of cells; nanomaterials and nanodevices for biomedicineOptogenetics - Employing light-activated channels and enzymes for manipulation of neural activity with temporal precision. The duration of unsolicited awards is generally one to three years. The average annual award size for the program is $100,000 for individual investigators and $200,000 for multiple investigators. Proposals requesting a substantially higher amount than this, without prior consultation with the Program Director, may be returned without review. Innovative proposals outside of these specific interest areas can be considered. However, prior to submission, it is recommended that the PI contact the Program Director to avoid the possibility of the proposal being returned without review.Additional Program Information - 7236: (e.g., Areas of Research, Research Highlights, Conferences and Workshops, Program Director Information, etc.) ---------------------------------------------------------------------------------------------------INFORMATION COMMON TO MOST CBET PROGRAMSProposals should address the novelty and/or potentially transformative nature http://www.nsf.gov/about/transformative_research/faq.jsp of the concept being proposed, compared to previous work in the field. Also, it is important to address why the proposed work is important in terms of engineering science, as well as to also project the potential impact on society and /or industry of success in the research. The novelty or potentially transformative nature of the research should be included, as a minimum, in the Project Summary of each proposal. Proposals submitted to this program are subject to the scope of the program's description and the availability of funds. Decisions about particular proposals are often very difficult to make and factors other than reviewer comments and ratings enter into the decision. Maintaining appropriate balance among subfields, the availability of other funding, the total amount of funds available to the program, and general Foundation policies and priorities are also important decision factors. Faculty Early Career Development (CAREER) program proposals are strongly encouraged. Award duration is five years. The submission deadline for Engineering CAREER proposals is in July every year. Please see the following URL for more information: http://www.nsf.gov/funding/pgm_summ.jsp?pims_id=503214Proposals for Conferences, Workshops, and Supplements: Proposals involving these activities should ideally be submitted during the regular annual proposal window. PIs are strongly encouraged to discuss their requests with the Program Director before submission of the proposal.Grants for Rapid Response Research (RAPID) and EArly-concept Grants for Exploratory Research (EAGER) are also considered when appropriate. Please note that proposals of these types must be discussed with the program director before submission. Further details are available in the Proposal and Award Policies and Procedures Guide (PAPPG) download. Proposals received outside of the Announced Proposal Window dates will be returned without review..