ForecastedOpportunity RFA-AI-28-014

Precision and Systems Biology to Uncover the Link Between Chronic and Infectious Diseases

National Institutes of Health · Department of Health and Human Services

At a glance

Precision and Systems Biology to Uncover the Link Between Chronic and Infectious Diseases is a forecasted federal cooperative agreement opportunity from the National Institutes of Health (Department of Health and Human Services). The agency's forecast estimates an application due date of January 22, 2027; forecast dates can change. Total estimated funding is $17.5M across about 10 awards. Applicant types listed as eligible include state governments, county governments, city or township governments, special district governments, independent school districts and 10 more. Cost sharing is not required. It is funded under Assistance Listing 93.855 (Allergy and Infectious Diseases Research) and 1 other listing.

Summary assembled from the official notice's fields. The official notice governs.

Key facts

Jun 24, 2026Forecast posted
Nov 6, 2026 (est.)Full notice expectednext date
Jan 22, 2027 (est.)Application deadline
Jan 1, 2028 (est.)Est. award date

Posted: Jun 24, 2026
Est. close date: Jan 22, 2027
Est. award date: Jan 1, 2028
Award floor: Not specified
Award ceiling: Not specified
Est. total funding: $17,500,000
Expected awards: 10
Cost sharing: Not required
Funding instrument: Cooperative Agreement
Opportunity category: Discretionary
Fiscal year: FY2028

Who can apply

State governments
County governments
City or township governments
Special district governments
Independent school districts
Public colleges & universities
Federally recognized tribal governments
Public & Indian housing authorities
Native American tribal organizations
501(c)(3) nonprofits
Nonprofits without 501(c)(3) status
Private colleges & universities
For-profit organizations (not small businesses)
Small businesses
Others (see notice)

Additional information on eligibility (from the notice)

Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;Non-domestic (non-U.S.) Entities (Foreign Institutions).

Can your organization apply?

A quick check against the listed applicant types — other requirements in the notice still apply.

Based on the published notice. Review the official notice for complete eligibility requirements.

What it funds

Official synopsis as published by the agency, formatted for readability.

The National Institute of Allergy and Infectious Diseases (NIAID) seeks to advance its mission by supporting multidisciplinary, consortium-based research using precision systems biology approaches to uncover links among chronic illnesses, infectious diseases and microbiomes. There is an urgent scientific and clinical need to understand the pathways by which infections lead to chronic lifelong health issues or alternatively, how long-term illnesses might predispose or exacerbate acute infections. The objective is to harness cutting-edge technologies along with longitudinal patient cohorts and biobank data for comprehensive analysis of genetic, environmental, and lifestyle factors leading to advances in prevention and treatment strategies for both chronic and infectious diseases. The cutting-edge technologies may include multi-omics, computational modeling, artificial intelligence, organoid-based validation systems, and integration of real-world data, alongside improved access to digital health records and advanced clinical informatics tools. The goal is to generate meaningful insights into disease progression and host-pathogen interactions. Grant authorities that allow NIAID to forecast this opportunity are as follows: Sections 301 and 405 of the Public Health Service Act as amended (42 USC 241 and 284) and under Federal Regulations 42 CFR Part 52 and 2 CFR Part 200.

How to apply

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Read the full announcement (NOFO)Eligibility, evaluation criteria, page limits and required attachments are in the full notice on Grants.gov. Open ↗
Confirm eligibility and fitCheck your organization type above; no cost sharing is required.
Register (or renew) in SAM.gov and get a UEIFree. New registrations can take several weeks; registrations must be renewed every year. Open ↗
Set up Grants.gov accessCreate a Grants.gov account and make sure someone has the Authorized Organization Representative (AOR) role. Open ↗
Watch for the full noticeThe agency estimates posting it around November 6, 2026. Save this grant to track changes.
Prepare narrative, budget and attachmentsFollow the notice's format exactly — page limits and required forms are common reasons applications are rejected.
Ask the agency contact any questions earlyNIAID OGAT (Division of Microbiology and Infectious Diseases) · NIAIDOGAT@mail.nih.gov Open ↗
Submit before January 22, 2027Submit a few days early and keep your Grants.gov confirmation and validation emails.

Assistance Listings

What is an ALN?

Reported obligations under ALN 93.855

Historical data · not a prediction

FY24

$4.07B

FY25

$4.38B

FY26

$4.3B est.

Source: SAM.gov Assistance Listing 93.855. Program-wide totals, not awards from this specific opportunity.

Agency contact (as published)

NIAID OGAT (Division of Microbiology and Infectious Diseases)
NIAIDOGAT@mail.nih.gov
Please contact via email.

Quick answers

Is “Precision and Systems Biology to Uncover the Link Between Chronic and Infectious Diseases” open for applications yet?

Not yet. It is a forecast — an agency's advance notice of an expected opportunity. The agency estimates posting the full notice around November 6, 2026. Forecast details and dates can change.

Who is eligible to apply for “Precision and Systems Biology to Uncover the Link Between Chronic and Infectious Diseases”?

The official notice lists these applicant types as eligible: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public colleges & universities, Federally recognized tribal governments, Public & Indian housing authorities, Native American tribal organizations, 501(c)(3) nonprofits, Nonprofits without 501(c)(3) status, Private colleges & universities and 3 more. Additional restrictions may apply; review the full notice.

How much funding is available through “Precision and Systems Biology to Uncover the Link Between Chronic and Infectious Diseases”?

Per the notice, total estimated program funding is $17,500,000 and the agency expects to make about 10 awards.

How do I apply for “Precision and Systems Biology to Uncover the Link Between Chronic and Infectious Diseases”?

Applications are submitted through the official source, not through GrantsJunction. Open the official notice on Grants.gov (opportunity RFA-AI-28-014), and review the full announcement and application package. Organizations applying through Grants.gov generally need an active SAM.gov registration and a Grants.gov account, which can take several weeks to set up.

Matched on shared Assistance Listings, agency, categories and eligible applicant types.

OpenALN 93.113, 93.121…