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ForecastedResearch announcementOpportunity RFA-DK-27-122

Single Source for the Continuation of the Physiology of the Weight Reduced State (POWERS) Study (U01- Clinical Trials Required)

National Institutes of Health · Department of Health and Human Services

At a glance

Single Source for the Continuation of the Physiology of the Weight Reduced State (POWERS) Study (U01- Clinical Trials Required) is a forecasted federal cooperative agreement opportunity from the National Institutes of Health (Department of Health and Human Services). The agency's forecast estimates an application due date of July 1, 2026; forecast dates can change. Applicant types listed as eligible include others (see notice). Cost sharing is not required. It is funded under Assistance Listing 93.847 (Diabetes, Digestive, and Kidney Diseases Extramural Research).

Summary assembled from the official notice's fields. The official notice governs.

Key facts

  1. Sep 18, 2025Forecast posted
  2. Apr 1, 2026 (est.)Full notice expected
  3. Jul 1, 2026 (est.)Application deadline
  4. Apr 1, 2027 (est.)Est. award datenext date
Posted
Sep 18, 2025
Est. close date
Jul 1, 2026
Est. award date
Apr 1, 2027
Award floor
Not specified
Award ceiling
Not specified
Est. total funding
Not specified
Expected awards
1
Cost sharing
Not required
Funding instrument
Cooperative Agreement
Opportunity category
Discretionary
Fiscal year
FY2027

Typical awards for this program (SAM.gov listing for ALN 93.847, not this notice): Project Grants: Range of $1,300 to $10,834,000; $418,000 average NRSAs: Range of $2,500 to $869,000; $116,000 average SBIR: Range of $6,500 to $2,074,000; $585,000 average

Who can apply

  • Others (see notice)

Additional information on eligibility (from the notice)

NIDDK requests a Single Source competition for the Continuation of the Physiology of the Weight Reduced State (POWERS) Study at the University of Pittsburgh.

A quick check against the listed applicant types — other requirements in the notice still apply.

Based on the published notice. Review the official notice for complete eligibility requirements.

What it funds

Official synopsis as published by the agency, formatted for readability.

The purpose of this NOFO is to continue the Physiology of the Weight Reduced State (POWERS) study. The goal of POWERS is to understand the physiological processes underlying individual variability in weight regain following weight loss. The continuation of POWERS will allow for the completion of the clinical trial and analysis of data and biospecimens.

How to apply

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Assistance Listing

What is an ALN?

Reported obligations under ALN 93.847

Historical data · not a prediction
FY24$1.97B
FY25$2.04B
FY26$111M est.
Source: SAM.gov Assistance Listing 93.847. Program-wide totals, not awards from this specific opportunity.

Agency contact (as published)

Mary Evans, PhD
NIDDK_Obesity@nih.gov
301-594-4578

Quick answers

Is this opportunity open for applications yet?

Not yet. It is a forecast — an agency's advance notice of an expected opportunity. The agency estimates posting the full notice around April 1, 2026. Forecast details and dates can change.

Who is eligible to apply for this opportunity?

The official notice lists these applicant types as eligible: Others (see notice). Additional restrictions may apply; review the full notice.

How do I apply for this opportunity?

Applications are submitted through the official source, not through GrantsJunction. Open the official notice on Grants.gov (opportunity RFA-DK-27-122), and review the full announcement and application package. Organizations applying through Grants.gov generally need an active SAM.gov registration and a Grants.gov account, which can take several weeks to set up.

Matched on shared Assistance Listings, agency, categories and eligible applicant types.