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ForecastedResearch announcementOpportunity RFA-DK-27-130

Limited Competition: Chronic Kidney Diseases of UnceRtain Etiology (CKDu) in Agricultural Communities (CURE) Research Consortium- Field Epidemiology Sites

National Institutes of Health · Department of Health and Human Services

At a glance

Limited Competition: Chronic Kidney Diseases of UnceRtain Etiology (CKDu) in Agricultural Communities (CURE) Research Consortium- Field Epidemiology Sites is a forecasted federal cooperative agreement opportunity from the National Institutes of Health (Department of Health and Human Services). The agency's forecast estimates an application due date of July 1, 2026; forecast dates can change. Total estimated funding is $6M across about 5 awards. Applicant types listed as eligible include state governments, county governments, public colleges & universities, federally recognized tribal governments, public & indian housing authorities and 5 more. Cost sharing is not required. It is funded under Assistance Listing 93.847 (Diabetes, Digestive, and Kidney Diseases Extramural Research).

Summary assembled from the official notice's fields. The official notice governs.

Key facts

  1. Sep 30, 2025Forecast posted
  2. Apr 1, 2026 (est.)Full notice expected
  3. Jul 1, 2026 (est.)Application deadline
  4. Jan 1, 2027 (est.)Est. award datenext date
Posted
Sep 30, 2025
Est. close date
Jul 1, 2026
Est. award date
Jan 1, 2027
Award floor
Not specified
Award ceiling
Not specified
Est. total funding
$6,000,000
Implied average award
$1,200,000 calculated
Expected awards
5
Cost sharing
Not required
Funding instrument
Cooperative Agreement
Opportunity category
Discretionary
Fiscal year
FY2027

Typical awards for this program (SAM.gov listing for ALN 93.847, not this notice): Project Grants: Range of $1,300 to $10,834,000; $418,000 average NRSAs: Range of $2,500 to $869,000; $116,000 average SBIR: Range of $6,500 to $2,074,000; $585,000 average

Implied average = estimated total funding ÷ expected number of awards, calculated by GrantsJunction. Actual awards vary.

Who can apply

  • State governments
  • County governments
  • Public colleges & universities
  • Federally recognized tribal governments
  • Public & Indian housing authorities
  • Native American tribal organizations
  • Private colleges & universities
  • For-profit organizations (not small businesses)
  • Small businesses
  • Others (see notice)

Additional information on eligibility (from the notice)

Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;Non-domestic (non-U.S.) Entities (Foreign Institutions).

Also named in the notice's eligibility text
  • 501(c)(3) nonprofits
  • Nonprofits without 501(c)(3) status
Matched from the wording above by GrantsJunction — confirm in the full announcement.

A quick check against the listed applicant types — other requirements in the notice still apply.

Based on the published notice. Review the official notice for complete eligibility requirements.

What it funds

Official synopsis as published by the agency, formatted for readability.

The purpose of this funding opportunity is to advance the NIH mission by supporting the continuation of the Consortium to Study Chronic Kidney Disease of UnceRtain Etiology (CKDu) in Agricultural Communities (CURE).

Chronic Kidney Disease of Uncertain Etiology (CKDu) causes kidney failure in rural areas of many Low and Middle Income Countries, resulting in a large death toll among the young working age population. Environmental factors are suspected to be causative, but family and geographic clustering add consideration of unrecognized genetic susceptibility. The risk factors identified in other countries are encountered by U.S. patients, so this research will offer valuable insights into the development and progression of tubulointerstitial renal diseases, with broad implications for understanding kidney health and disease in the U.S.

NIDDK, NIEHS, and FIC have jointly funded a consortium that includes Field Epidemiology Sites, a Renal and Environmental Science Core, and a Data Coordinating Center to find causes and potential interventions for CKDu since 2021. This NOFO requests renewal applications for the Field Epidemiology Sites that will continue to identify, recruit, and retain participants in CKDu endemic areas, conduct study visits, and collect biological and environmental samples. Consortium members will continue to collaborate to maximize scientific opportunities and enable discovery science to understand the etiologies of CKDu, the exposures that initiate and affect progression of tubulointerstitial kidney disease, potential therapeutic targets, and future opportunities for public health interventions. The CURE Consortium will serve as a resource for ancillary studies. 

This is a forecast for a limited competition Notice of Funding Opportunity (NOFO) that will invite application(s) from eligible organizations to apply. Application(s) will be peer-reviewed and only funded if meritorious.

How to apply

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Assistance Listing

What is an ALN?

Reported obligations under ALN 93.847

Historical data · not a prediction
FY24$1.97B
FY25$2.04B
FY26$111M est.
Source: SAM.gov Assistance Listing 93.847. Program-wide totals, not awards from this specific opportunity.

Agency contact (as published)

Susan Mendley
susan.mendley@nih.gov
301.827.1861

Quick answers

Is this opportunity open for applications yet?

Not yet. It is a forecast — an agency's advance notice of an expected opportunity. The agency estimates posting the full notice around April 1, 2026. Forecast details and dates can change.

Who is eligible to apply for this opportunity?

The official notice lists these applicant types as eligible: State governments, County governments, Public colleges & universities, Federally recognized tribal governments, Public & Indian housing authorities, Native American tribal organizations, Private colleges & universities, For-profit organizations (not small businesses), Small businesses and Others (see notice). Additional restrictions may apply; review the full notice.

How much funding is available through this opportunity?

Per the notice, total estimated program funding is $6,000,000 and the agency expects to make about 5 awards.

How do I apply for this opportunity?

Applications are submitted through the official source, not through GrantsJunction. Open the official notice on Grants.gov (opportunity RFA-DK-27-130), and review the full announcement and application package. Organizations applying through Grants.gov generally need an active SAM.gov registration and a Grants.gov account, which can take several weeks to set up.

Matched on shared Assistance Listings, agency, categories and eligible applicant types.