Independent research tool — not a government agency. Official notices govern.Refreshed
GrantsJunctionAmerican funding, sourcedMethodology
ForecastedResearch announcementOpportunity RFA-ES-27-009

Mechanistic Toxicology of METALS: Metal Exposure, Transport, Action, Localization, and Susceptibility (RP1 Clinical Trial Not Allowed)

National Institutes of Health · Department of Health and Human Services

At a glance

Mechanistic Toxicology of METALS: Metal Exposure, Transport, Action, Localization, and Susceptibility (RP1 Clinical Trial Not Allowed) is a forecasted federal grant opportunity from the National Institutes of Health (Department of Health and Human Services). The agency's forecast estimates an application due date of January 5, 2027; forecast dates can change. Individual awards are listed as $100K – $500K, with about 20 awards expected and $15M in total estimated funding. Applicant types listed as eligible include state governments, county governments, city or township governments, special district governments, independent school districts and 10 more. Cost sharing is not required. It is funded under Assistance Listing 93.113 (Environmental Health).

Summary assembled from the official notice's fields. The official notice governs.

Key facts

  1. Sep 14, 2026Forecast posted
  2. Dec 4, 2026 (est.)Full notice expectednext date
  3. Jan 5, 2027 (est.)Application deadline
  4. Jul 31, 2027 (est.)Est. award date
Posted
Sep 14, 2026
Est. close date
Jan 5, 2027
Est. award date
Jul 31, 2027
Award floor
$100,000
Award ceiling
$500,000
Est. total funding
$15,000,000
Expected awards
20
Cost sharing
Not required
Funding instrument
Grant
Opportunity category
Discretionary
Fiscal year
FY2027

Who can apply

  • State governments
  • County governments
  • City or township governments
  • Special district governments
  • Independent school districts
  • Public colleges & universities
  • Federally recognized tribal governments
  • Public & Indian housing authorities
  • Native American tribal organizations
  • 501(c)(3) nonprofits
  • Nonprofits without 501(c)(3) status
  • Private colleges & universities
  • For-profit organizations (not small businesses)
  • Small businesses
  • Others (see notice)

Additional information on eligibility (from the notice)

Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;

A quick check against the listed applicant types — other requirements in the notice still apply.

Based on the published notice. Review the official notice for complete eligibility requirements.

What it funds

Official synopsis as published by the agency, formatted for readability.

The purpose of this funding opportunity is to support mechanistic research to understand how exposure to metals and metal-containing compounds alters biological processes relevant to human health. Of particular interest are studies that elucidate the absorption, distribution, transport, cellular trafficking, biological interactions, and mechanisms of action of metals, including mechanisms through which metals may alter immune homeostasis, cross the placental barrier, or gain access to and affect the central nervous system. Studies may employ experimental models, new approach methodologies, computational approaches, or leverage human biospecimens where these approaches are used to address defined mechanistic hypotheses.

How to apply

0 of 8 done · progress saved in this browser

Assistance Listing

What is an ALN?

Reported obligations under ALN 93.113

Historical data · not a prediction
FY24$446M
FY25$466M
FY26$40.3M est.
Source: SAM.gov Assistance Listing 93.113. Program-wide totals, not awards from this specific opportunity.

Who was funded under ALN 93.113

Historical data · not a prediction

Since October 1, 2023, 2,194 grant awards had funding actions under Environmental Health, with 1,535 sub-awards passed on to other organizations. These are program-wide awards, not awards from this specific notice.

  1. ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI$58.1M
  2. EMORY UNIVERSITY$45.3M
  3. THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK$42.7M
  4. UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL$41.1M
  5. NEW YORK UNIVERSITY$39.8M
Recipients, states, recent awards and sub-awards →Source: USAspending.gov.

Agency contact (as published)

NOFO.information@niehs.nih.gov
NOFO.information@niehs.nih.gov
Please contact via email.

Quick answers

Is this opportunity open for applications yet?

Not yet. It is a forecast — an agency's advance notice of an expected opportunity. The agency estimates posting the full notice around December 4, 2026. Forecast details and dates can change.

Who is eligible to apply for this opportunity?

The official notice names these applicant types as eligible: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public colleges & universities, Federally recognized tribal governments, Public & Indian housing authorities, Native American tribal organizations, 501(c)(3) nonprofits, Nonprofits without 501(c)(3) status, Private colleges & universities and 3 more. Additional restrictions may apply; review the full notice.

How much funding is available through this opportunity?

Per the notice, individual awards are listed as $100k – $500k, total estimated program funding is $15,000,000 and the agency expects to make about 20 awards.

How do I apply for this opportunity?

Applications are submitted through the official source, not through GrantsJunction. Open the official notice on Grants.gov (opportunity RFA-ES-27-009), and review the full announcement and application package. Organizations applying through Grants.gov generally need an active SAM.gov registration and a Grants.gov account, which can take several weeks to set up.

Matched on shared Assistance Listings, agency, categories and eligible applicant types.