ForecastedResearch announcementOpportunity RFA-HG-27-009

Genomic Variant Interactions With Other Variants Or The Environment (UM1 Clinical Trials Not Allowed)

National Institutes of Health · Department of Health and Human Services

At a glance

Genomic Variant Interactions With Other Variants Or The Environment (UM1 Clinical Trials Not Allowed) is a forecasted federal cooperative agreement opportunity from the National Institutes of Health (Department of Health and Human Services). The agency's forecast estimates an application due date of August 22, 2025; forecast dates can change. Total estimated funding is $10M across about 5 awards. Applicant types listed as eligible include state governments, county governments, independent school districts, public colleges & universities, federally recognized tribal governments and 6 more. Cost sharing is not required. It is funded under Assistance Listing 93.172 (Human Genome Research).

Summary assembled from the official notice's fields. The official notice governs.

Key facts

Jun 6, 2025Forecast posted
Jun 23, 2025 (est.)Full notice expected
Aug 22, 2025 (est.)Application deadline
May 25, 2026 (est.)Est. award date

Posted: Jun 6, 2025
Est. close date: Aug 22, 2025
Est. award date: May 25, 2026
Award floor: Not specified
Award ceiling: Not specified
Est. total funding: $10,000,000
Implied average award: $2,000,000 calculated
Expected awards: 5
Cost sharing: Not required
Funding instrument: Cooperative Agreement
Opportunity category: Discretionary
Fiscal year: FY2026

Typical awards for this program (SAM.gov listing for ALN 93.172, not this notice): For Research project grants the range is from $26,000 - $19,996,553.

Implied average = estimated total funding ÷ expected number of awards, calculated by GrantsJunction. Actual awards vary.

Who can apply

State governments
County governments
Independent school districts
Public colleges & universities
Federally recognized tribal governments
Public & Indian housing authorities
Native American tribal organizations
501(c)(3) nonprofits
Private colleges & universities
For-profit organizations (not small businesses)
Small businesses

Additional information on eligibility (from the notice)

Non-domestic (non-U.S.) Entities (Foreign Organizations) are eligible to apply; Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply; Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

Can your organization apply?

A quick check against the listed applicant types — other requirements in the notice still apply.

Based on the published notice. Review the official notice for complete eligibility requirements.

What it funds

Official synopsis as published by the agency, formatted for readability.

The National Human Genome Research Institute (NHGRI) intends to promote a new initiative by publishing a Notice of Funding Opportunity (NOFO) to solicit applications to study the effects of genetic or environmental interactions on genomic variant impact. To accomplish this, centers funded through this initiative will propose a research framework to investigate whether interactions, with effects beyond additive, are important modifiers of the impact of variants. Centers will apply their framework to experimentally test combinations for interactions. The rationale for this research is the identification of a structure within the interaction landscape might result in better predictions of the most important interactions to test, leading to more effective variant testing, better understanding of Genome-wide Association Studies (GWAS), and improved polygenic scores. As IGVF Consortium members, centers will work together to ensure all consortium resources are accessible to a wide variety of potential users. Centers are also expected to collaborate with other consortium components to coordinate assays, variants, and cell types, and to develop shared analysis strategies to meet consortium goals.

This Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. The NOFO is expected to be published in 2025 with an expected application due date in 2025. This NOFO will utilize the UM1 activity code.

How to apply

0 of 8 done · progress saved in this browser

Read the full announcement (NOFO)Eligibility, evaluation criteria, page limits and required attachments are in the full notice on Grants.gov. Open ↗
Confirm eligibility and fitCheck your organization type above; no cost sharing is required.
Register (or renew) in SAM.gov and get a UEIFree. New registrations can take several weeks; registrations must be renewed every year. Open ↗
Set up Grants.gov accessCreate a Grants.gov account and make sure someone has the Authorized Organization Representative (AOR) role. Open ↗
Watch for the full noticeThe agency estimates posting it around June 23, 2025. Save this grant to track changes.
Prepare narrative, budget and attachmentsFollow the notice's format exactly — page limits and required forms are common reasons applications are rejected.
Ask the agency contact any questions earlyMike Pazin National Human Genome Research Institute (NHGRI) · michael.pazin@nih.gov Open ↗
Submit before August 22, 2025Submit a few days early and keep your Grants.gov confirmation and validation emails.

Assistance Listing

What is an ALN?

93.172Human Genome ResearchProgram →

Reported obligations under ALN 93.172

Historical data · not a prediction

FY24

$453M

FY25

$424M

FY26

$9.99M est.

Source: SAM.gov Assistance Listing 93.172. Program-wide totals, not awards from this specific opportunity.

Agency contact (as published)

Mike Pazin National Human Genome Research Institute (NHGRI)
michael.pazin@nih.gov
301-480-2629

Changes we detected

Oct 9, 2026: Close date changed

Quick answers

Is this opportunity open for applications yet?

Not yet. It is a forecast — an agency's advance notice of an expected opportunity. The agency estimates posting the full notice around June 23, 2025. Forecast details and dates can change.

Who is eligible to apply for this opportunity?

The official notice lists these applicant types as eligible: State governments, County governments, Independent school districts, Public colleges & universities, Federally recognized tribal governments, Public & Indian housing authorities, Native American tribal organizations, 501(c)(3) nonprofits, Private colleges & universities, For-profit organizations (not small businesses) and Small businesses. Additional restrictions may apply; review the full notice.

How much funding is available through this opportunity?

Per the notice, total estimated program funding is $10,000,000 and the agency expects to make about 5 awards.

How do I apply for this opportunity?

Applications are submitted through the official source, not through GrantsJunction. Open the official notice on Grants.gov (opportunity RFA-HG-27-009), and review the full announcement and application package. Organizations applying through Grants.gov generally need an active SAM.gov registration and a Grants.gov account, which can take several weeks to set up.

Matched on shared Assistance Listings, agency, categories and eligible applicant types.

ForecastedResearchALN 93.172