ForecastedResearch announcementOpportunity RFA-HG-28-003

ancient DNA for Modern Genomics (aDMG) Research Projects (U01 Clinical Trials Not Allowed)

National Institutes of Health · Department of Health and Human Services

At a glance

ancient DNA for Modern Genomics (aDMG) Research Projects (U01 Clinical Trials Not Allowed) is a forecasted federal cooperative agreement opportunity from the National Institutes of Health (Department of Health and Human Services). The agency's forecast estimates an application due date of February 1, 2028; forecast dates can change. Applicant types listed as eligible include state governments, county governments, city or township governments, special district governments, independent school districts and 10 more. Cost sharing is not required. It is funded under Assistance Listing 93.172 (Human Genome Research).

Summary assembled from the official notice's fields. The official notice governs.

Key facts

Jun 2, 2026Forecast posted
Aug 3, 2027 (est.)Full notice expectednext date
Feb 1, 2028 (est.)Application deadline
Sep 1, 2028 (est.)Est. award date

Posted: Jun 2, 2026
Est. close date: Feb 1, 2028
Est. award date: Sep 1, 2028
Award floor: Not specified
Award ceiling: Not specified
Est. total funding: Not specified
Expected awards: Not specified
Cost sharing: Not required
Funding instrument: Cooperative Agreement
Opportunity category: Discretionary
Fiscal year: FY2028

Typical awards for this program (SAM.gov listing for ALN 93.172, not this notice): For Research project grants the range is from $26,000 - $19,996,553.

Who can apply

State governments
County governments
City or township governments
Special district governments
Independent school districts
Public colleges & universities
Federally recognized tribal governments
Public & Indian housing authorities
Native American tribal organizations
501(c)(3) nonprofits
Nonprofits without 501(c)(3) status
Private colleges & universities
For-profit organizations (not small businesses)
Small businesses
Others (see notice)

Additional information on eligibility (from the notice)

Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;Non-domestic (non-U.S.) Entities (Foreign Institutions).

Can your organization apply?

A quick check against the listed applicant types — other requirements in the notice still apply.

Based on the published notice. Review the official notice for complete eligibility requirements.

What it funds

Official synopsis as published by the agency, formatted for readability.

The National Human Genome Research Institute (NHGRI) intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications to establish an ancient DNA for Modern Genomics (aDMG) program. The goal of aDMG is to establish an ethical resource of ancient and historical human DNA (aDNA) data to advance studies about contemporary human traits and biology. This NOFO aims to solicit applications that will leverage existing and newly generated aDNA data from this consortium to advance the biological and epidemiological understanding of modern human diseases and health-related traits by integrating aDNA with modern human and other species’ data. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO will utilize the U01 activity code. Investigators with expertise and insights into this area of ancient DNA and population genomics are encouraged to begin to consider applying for this new NOFO. In addition, collaborative investigations combining expertise in DNA sequencing methods and technology, computational genomics and data science, human evolution, and ancient human populations will be encouraged and these investigators should also begin considering applying for this application.

How to apply

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Read the full announcement (NOFO)Eligibility, evaluation criteria, page limits and required attachments are in the full notice on Grants.gov. Open ↗
Confirm eligibility and fitCheck your organization type above; no cost sharing is required.
Register (or renew) in SAM.gov and get a UEIFree. New registrations can take several weeks; registrations must be renewed every year. Open ↗
Set up Grants.gov accessCreate a Grants.gov account and make sure someone has the Authorized Organization Representative (AOR) role. Open ↗
Watch for the full noticeThe agency estimates posting it around August 3, 2027. Save this grant to track changes.
Prepare narrative, budget and attachmentsFollow the notice's format exactly — page limits and required forms are common reasons applications are rejected.
Ask the agency contact any questions earlyNHGRI Research Funding · nhgri-research-funding@mail.nih.gov Open ↗
Submit before February 1, 2028Submit a few days early and keep your Grants.gov confirmation and validation emails.

Assistance Listing

What is an ALN?

93.172Human Genome ResearchProgram →

Reported obligations under ALN 93.172

Historical data · not a prediction

FY24

$453M

FY25

$424M

FY26

$9.99M est.

Source: SAM.gov Assistance Listing 93.172. Program-wide totals, not awards from this specific opportunity.

Who was funded under ALN 93.172

Historical data · not a prediction

Since October 1, 2023, 1,329 grant awards had funding actions under Human Genome Research, with 1,049 sub-awards passed on to other organizations. These are program-wide awards, not awards from this specific notice.

THE LELAND STANFORD JUNIOR UNIVERSITY$85M
THE BROAD INSTITUTE, INC$76.7M
UNIVERSITY OF WASHINGTON$73M
UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL$40.7M
YALE UNIV$36.2M

Recipients, states, recent awards and sub-awards →Source: USAspending.gov.

Agency contact (as published)

NHGRI Research Funding
nhgri-research-funding@mail.nih.gov
Please contact via e-mail.

Quick answers

Is “ancient DNA for Modern Genomics (aDMG) Research Projects (U01 Clinical Trials Not Allowed)” open for applications yet?

Not yet. It is a forecast — an agency's advance notice of an expected opportunity. The agency estimates posting the full notice around August 3, 2027. Forecast details and dates can change.

Who is eligible to apply for “ancient DNA for Modern Genomics (aDMG) Research Projects (U01 Clinical Trials Not Allowed)”?

The official notice names these applicant types as eligible: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public colleges & universities, Federally recognized tribal governments, Public & Indian housing authorities, Native American tribal organizations, 501(c)(3) nonprofits, Nonprofits without 501(c)(3) status, Private colleges & universities and 3 more. Additional restrictions may apply; review the full notice.

How do I apply for “ancient DNA for Modern Genomics (aDMG) Research Projects (U01 Clinical Trials Not Allowed)”?

Applications are submitted through the official source, not through GrantsJunction. Open the official notice on Grants.gov (opportunity RFA-HG-28-003), and review the full announcement and application package. Organizations applying through Grants.gov generally need an active SAM.gov registration and a Grants.gov account, which can take several weeks to set up.

Matched on shared Assistance Listings, agency, categories and eligible applicant types.

ForecastedResearchALN 93.172