ClosedResearch announcementOpportunity RFA-RM-27-003

NIH Director’s Transformative Research Award for Individual and Group Science (R01 Clinical Trial Optional)

National Institutes of Health · Department of Health and Human Services

At a glance

NIH Director’s Transformative Research Award for Individual and Group Science (R01 Clinical Trial Optional) is a closed federal grant opportunity from the National Institutes of Health (Department of Health and Human Services). The application deadline was September 3, 2026. Total estimated funding is $8M across about 7 awards. Applicant types listed as eligible include state governments, county governments, city or township governments, special district governments, independent school districts and 10 more. Cost sharing is not required. It is funded under Assistance Listing 93.310 (Trans-NIH Research Support).

Summary assembled from the official notice's fields. The official notice governs.

Key facts

Jun 29, 2026Posted
Sep 3, 2026Application deadline
Aug 30, 2027 (est.)Est. award datenext date
Nov 2, 2026Archived

Posted: Jun 29, 2026
Close date: Sep 3, 2026
Archive date: Nov 2, 2026
Est. award date: Aug 30, 2027
Award floor: Not specified
Award ceiling: Not specified
Est. total funding: $8,000,000
Implied average award: $1,142,857 calculated
Expected awards: 7
Cost sharing: Not required
Funding instrument: Grant
Opportunity category: Discretionary

Typical awards for this program (SAM.gov listing for ALN 93.310, not this notice): $3,000 to $27,999,994 with the average being $640,952.

Implied average = estimated total funding ÷ expected number of awards, calculated by GrantsJunction. Actual awards vary.

Who can apply

State governments
County governments
City or township governments
Special district governments
Independent school districts
Public colleges & universities
Federally recognized tribal governments
Public & Indian housing authorities
Native American tribal organizations
501(c)(3) nonprofits
Nonprofits without 501(c)(3) status
Private colleges & universities
For-profit organizations (not small businesses)
Small businesses
Others (see notice)

Additional information on eligibility (from the notice)

Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International Collaborations:Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

Can your organization apply?

A quick check against the listed applicant types — other requirements in the notice still apply.

Based on the published notice. Review the official notice for complete eligibility requirements.

What it funds

Official synopsis as published by the agency, formatted for readability.

The NIH Director"s Transformative Research Award supports individual scientists or groups of scientists proposing bold, groundbreaking, exceptionally innovative, original, and/or unconventional research with the potential to create new scientific paradigms, establish entirely new and improved clinical approaches, or develop transformative technologies. Applications in any area within the biomedical sciences are welcome; topics may involve basic, translational, or clinical research. No preliminary data are required. Projects must clearly demonstrate, based on the strength of the logic, a compelling potential to produce a major impact in a broad area of relevance to the NIH. The NIH Director"s Transformative Research Award is a component of the High-Risk, High-Reward Research (HRHR) program of the NIH Common Fund.

Full announcement & documents

The full announcement has the complete rules — page limits, required attachments, evaluation criteria and any letter-of-intent dates. Files download directly from Grants.gov.

RFA-RM-27-003-Full-Announcement.htmlFull Announcement · RFA-RM-27-003-Full-Announcement.htmlHTML · 120 KB

Assistance Listing

What is an ALN?

93.310Trans-NIH Research SupportProgram →

Reported obligations under ALN 93.310

Historical data · not a prediction

FY24

$1.17B

FY25

$1.06B

FY26

$28.1M est.

Source: SAM.gov Assistance Listing 93.310. Program-wide totals, not awards from this specific opportunity.

Agency contact (as published)

National Institutes of Health
Transformative_Awards@mail.nih.gov
301-402-2541

Quick answers

Who is eligible to apply for this opportunity?

The official notice lists these applicant types as eligible: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public colleges & universities, Federally recognized tribal governments, Public & Indian housing authorities, Native American tribal organizations, 501(c)(3) nonprofits, Nonprofits without 501(c)(3) status, Private colleges & universities and 3 more. Additional restrictions may apply; review the full notice.

How much funding is available through this opportunity?

Per the notice, total estimated program funding is $8,000,000 and the agency expects to make about 7 awards.

How do I apply for this opportunity?

Applications are submitted through the official source, not through GrantsJunction. Open the official notice on Grants.gov (opportunity RFA-RM-27-003), and review the full announcement and application package. Organizations applying through Grants.gov generally need an active SAM.gov registration and a Grants.gov account, which can take several weeks to set up.

Matched on shared Assistance Listings, agency, categories and eligible applicant types.

ForecastedResearchALN 93.310