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OpenResearch announcementOpportunity PAR-25-378

Intervention Research to Improve Native American Health (R34 Clinical Trial Optional)

National Institutes of Health · Department of Health and Human Services

At a glance

Intervention Research to Improve Native American Health (R34 Clinical Trial Optional) is an open federal grant opportunity from the National Institutes of Health (Department of Health and Human Services). Applications are due January 7, 2027. Applicant types listed as eligible include state governments, county governments, city or township governments, special district governments, independent school districts and 10 more. Cost sharing is not required. It is funded under Assistance Listing 93.113 (Environmental Health) and 10 other listings.

Summary assembled from the official notice's fields. The official notice governs.

Key facts

  1. Jan 22, 2025Posted
  2. Jan 7, 2027Application deadlinenext date
  3. Feb 6, 2027Archived
Posted
Jan 22, 2025
Close date
Jan 7, 2027
Archive date
Feb 6, 2027
Award floor
Not specified
Award ceiling
Not specified
Est. total funding
Not specified
Expected awards
Not specified
Cost sharing
Not required
Funding instrument
Grant
Opportunity category
Discretionary

Typical awards for this program (SAM.gov listing for ALN 93.113, not this notice): Range: $2,500 to $6,747,780 Average: $444,487

Who can apply

  • State governments
  • County governments
  • City or township governments
  • Special district governments
  • Independent school districts
  • Public colleges & universities
  • Federally recognized tribal governments
  • Public & Indian housing authorities
  • Native American tribal organizations
  • 501(c)(3) nonprofits
  • Nonprofits without 501(c)(3) status
  • Private colleges & universities
  • For-profit organizations (not small businesses)
  • Small businesses
  • Others (see notice)

Additional information on eligibility (from the notice)

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession; Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

A quick check against the listed applicant types — other requirements in the notice still apply.

Based on the published notice. Review the official notice for complete eligibility requirements.

What it funds

Official synopsis as published by the agency, formatted for readability.

The purpose of this notice of funding opportunity (NOFO) is to support research on interventions to improve health in Native American (NA) populations. This includes 1) etiologic research, where there is a significant gap in knowledge, that will directly inform intervention development or adaptations, 2) research that develops, adapts, or tests the efficacy or effectiveness of health promotion and disease prevention interventions, 3) research that tests culturally informed treatment or recovery interventions and 4) where a sufficient body of knowledge on intervention efficacy exists, research on dissemination and implementation that develops and tests strategies to overcome barriers to the adoption, integration, scale-up, and sustainability of effective interventions. Existing data suggest that significant acute and chronic disease inequities exist for NA populations. Concurrently, NA populations experience unique sociopolitical, historical, and environmental stressors and risks that may exacerbate health conditions and/or impact the effectiveness of existing solutions to address the conditions. They also possess unique strengths and resiliencies that can mitigate stressors or inform intervention strategies. Through this initiative, intervention and related research is sought to build upon community knowledge, resources, and resilience to test science-based, culturally appropriate solutions to reduce morbidity and mortality through identification and remediation of precursors to diseases and disorders and through culturally informed treatment. Interventions should be designed with a consideration for sustainability within the communities where they are tested, and have the flexibility to be readily adapted, disseminated, and scaled up to other communities where culturally appropriate. For the purposes of this NOFO, NA includes the following populations: Alaska Natives, American Indians (whose ancestral lands fall at least partially within the U.S. main land).

Additional information from the agency ↗

Full announcement & documents

The full announcement has the complete rules — page limits, required attachments, evaluation criteria and any letter-of-intent dates. Files download directly from Grants.gov.

How to apply

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Assistance Listings

What is an ALN?

Reported obligations under ALN 93.113

Historical data · not a prediction
FY24$446M
FY25$466M
FY26$40.3M est.
Source: SAM.gov Assistance Listing 93.113. Program-wide totals, not awards from this specific opportunity.

Who was funded under ALN 93.113

Historical data · not a prediction

Since October 1, 2023, 2,194 grant awards had funding actions under Environmental Health, with 1,535 sub-awards passed on to other organizations. These are program-wide awards, not awards from this specific notice.

  1. ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI$58.1M
  2. EMORY UNIVERSITY$45.3M
  3. THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK$42.7M
  4. UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL$41.1M
  5. NEW YORK UNIVERSITY$39.8M
Recipients, states, recent awards and sub-awards →Source: USAspending.gov.

Agency contact (as published)

National Institutes of Health
grantsinfo@nih.gov
301-402-2541

Places named in the notice

Alaska

Derived from the notice text. A place being named does not by itself restrict eligibility.

Quick answers

When is the deadline for “Intervention Research to Improve Native American Health (R34 Clinical Trial Optional)”?

According to the official notice, applications are due January 7, 2027. Confirm the deadline and submission time on Grants.gov before applying.

Who is eligible to apply for “Intervention Research to Improve Native American Health (R34 Clinical Trial Optional)”?

The official notice names these applicant types as eligible: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public colleges & universities, Federally recognized tribal governments, Public & Indian housing authorities, Native American tribal organizations, 501(c)(3) nonprofits, Nonprofits without 501(c)(3) status, Private colleges & universities and 3 more. Additional restrictions may apply; review the full notice.

How do I apply for “Intervention Research to Improve Native American Health (R34 Clinical Trial Optional)”?

Applications are submitted through the official source, not through GrantsJunction. Open the official notice on Grants.gov (opportunity PAR-25-378), and review the full announcement and application package. Organizations applying through Grants.gov generally need an active SAM.gov registration and a Grants.gov account, which can take several weeks to set up.

Matched on shared Assistance Listings, agency, categories and eligible applicant types.