OpenResearch announcementOpportunity PAR-26-042

Research Grants in Clinical Informatics (R01 Clinical Trial Optional)

National Institutes of Health · Department of Health and Human Services

At a glance

Research Grants in Clinical Informatics (R01 Clinical Trial Optional) is an open federal grant opportunity from the National Institutes of Health (Department of Health and Human Services). Applications are due March 5, 2029. Individual awards are listed as up to $250K, with about 10 awards expected and $2.5M in total estimated funding. Applicant types listed as eligible include state governments, county governments, city or township governments, special district governments, independent school districts and 10 more. Cost sharing is not required. It is funded under Assistance Listing 93.879 (Medical Library Assistance).

Summary assembled from the official notice's fields. The official notice governs.

Key facts

Feb 11, 2026Posted
Mar 5, 2029Application deadlinenext date
Dec 4, 2026 (est.)Est. award date
May 4, 2029Archived

Posted: Feb 11, 2026
Close date: Mar 5, 2029
Archive date: May 4, 2029
Est. award date: Dec 4, 2026
Award floor: Not specified
Award ceiling: $250,000
Est. total funding: $2,500,000
Expected awards: 10
Cost sharing: Not required
Funding instrument: Grant
Opportunity category: Discretionary

Who can apply

State governments
County governments
City or township governments
Special district governments
Independent school districts
Public colleges & universities
Federally recognized tribal governments
Public & Indian housing authorities
Native American tribal organizations
501(c)(3) nonprofits
Nonprofits without 501(c)(3) status
Private colleges & universities
For-profit organizations (not small businesses)
Small businesses
Others (see notice)

Additional information on eligibility (from the notice)

Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International CollaborationsNon-domestic (non-U.S.) Entities (Foreign Organizations) are eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.NIH will no longer issue awards (i.e., new, renewal, or non-competing continuation) to domestic or foreign entities that involve foreign subawards/subcontracts. All NIH-funded research involving foreign subawards/subcontracts must be submitted in response to a NOFO that is specifically designated for funded international collaborations. This new requirement was effective, May 1, 2025.Applications involving foreign subawards/subcontracts submitted in response to this NOFO will be deemed noncompliant and will not be considered for funding. This policy applies to all monetary international collaborations resulting in foreign subawards/subcontracts, however, it does not preclude unfunded international collaborations or foreign components, funding for foreign consultants, or procurement of unique equipment or supplies from foreign vendors.

Can your organization apply?

A quick check against the listed applicant types — other requirements in the notice still apply.

Based on the published notice. Review the official notice for complete eligibility requirements.

What it funds

Official synopsis as published by the agency, formatted for readability.

The National Library of Medicine (NLM) seeks applications for innovative research in clinical informatics. The overarching goal of this forthcoming program is to catalyze the development and advancement of novel informatics methodologies that empower clinicians, patients, and the broader public to better understand, manage, and improve health and health care delivery. This NOFO will support research focused on the design, implementation, and evaluation of clinical informatics tools and methods that enable data-driven discovery, promote evidence-based decision-making, and support personalized and precision health care. Emphasis will be placed on domain-independent, scalable, and reusable/reproducible approaches for the discovery, analysis, organization, and management of health-related digital objects—including electronic health records (EHRs), clinical notes, imaging data, and patient-generated data. The aim is to transform raw and heterogeneous health data into actionable knowledge, to develop innovative tools, and to implement practical applications that can be generalized across multiple clinical settings and populations. Projects should demonstrate the potential to accelerate scientific insights, improve clinical workflows, and ultimately lead to improved health outcomes.

Full announcement & documents

The full announcement has the complete rules — page limits, required attachments, evaluation criteria and any letter-of-intent dates. Files download directly from Grants.gov.

PAR-26-042-Full-Announcement.htmlFull Announcement · PAR-26-042-Full-Announcement.htmlHTML · 114 KB

How to apply

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Read the full announcement (NOFO)Eligibility, evaluation criteria, page limits and required attachments are in the full notice on Grants.gov. Open ↗
Confirm eligibility and fitCheck your organization type above; no cost sharing is required.
Register (or renew) in SAM.gov and get a UEIFree. New registrations can take several weeks; registrations must be renewed every year. Open ↗
Set up Grants.gov accessCreate a Grants.gov account and make sure someone has the Authorized Organization Representative (AOR) role. Open ↗
Open the application packageUse opportunity number PAR-26-042 on Grants.gov (Grants.gov Workspace). Open ↗
Prepare narrative, budget and attachmentsFollow the notice's format exactly — page limits and required forms are common reasons applications are rejected.
Ask the agency contact any questions earlyNational Institutes of Health · NLMProgram@nih.gov Open ↗
Submit before March 5, 2029Submit a few days early and keep your Grants.gov confirmation and validation emails.

Assistance Listing

What is an ALN?

93.879Medical Library AssistanceProgram →

Reported obligations under ALN 93.879

Historical data · not a prediction

FY24

$78.2M

FY25

$79.4M

FY26

$70.2M est.

Source: SAM.gov Assistance Listing 93.879. Program-wide totals, not awards from this specific opportunity.

Agency contact (as published)

National Institutes of Health
NLMProgram@nih.gov
301-402-2541

Quick answers

When is the deadline for “Research Grants in Clinical Informatics (R01 Clinical Trial Optional)”?

According to the official notice, applications are due March 5, 2029. Confirm the deadline and submission time on Grants.gov before applying.

Who is eligible to apply for “Research Grants in Clinical Informatics (R01 Clinical Trial Optional)”?

The official notice lists these applicant types as eligible: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public colleges & universities, Federally recognized tribal governments, Public & Indian housing authorities, Native American tribal organizations, 501(c)(3) nonprofits, Nonprofits without 501(c)(3) status, Private colleges & universities and 3 more. Additional restrictions may apply; review the full notice.

How much funding is available through “Research Grants in Clinical Informatics (R01 Clinical Trial Optional)”?

Per the notice, individual awards are listed as up to $250k, total estimated program funding is $2,500,000 and the agency expects to make about 10 awards.

How do I apply for “Research Grants in Clinical Informatics (R01 Clinical Trial Optional)”?

Applications are submitted through the official source, not through GrantsJunction. Open the official notice on Grants.gov (opportunity PAR-26-042), and review the full announcement and application package. Organizations applying through Grants.gov generally need an active SAM.gov registration and a Grants.gov account, which can take several weeks to set up.

Matched on shared Assistance Listings, agency, categories and eligible applicant types.

ForecastedResearchALN 93.879