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ForecastedResearch announcementOpportunity PAR-27-125

Multi-Site Investigator-Initiated Clinical Trials (Collaborative UG3/UH3 Clinical Trial Required)

National Institutes of Health · Department of Health and Human Services

At a glance

Multi-Site Investigator-Initiated Clinical Trials (Collaborative UG3/UH3 Clinical Trial Required) is a forecasted federal cooperative agreement opportunity from the National Institutes of Health (Department of Health and Human Services). The agency's forecast estimates an application due date of February 16, 2027; forecast dates can change. Applicant types listed as eligible include state governments, county governments, city or township governments, special district governments, independent school districts and 10 more. Cost sharing is not required. It is funded under Assistance Listing 93.233 (National Center on Sleep Disorders Research) and 4 other listings.

Summary assembled from the official notice's fields. The official notice governs.

Key facts

  1. Jul 1, 2026Forecast posted
  2. Nov 16, 2026 (est.)Full notice expectednext date
  3. Feb 16, 2027 (est.)Application deadline
  4. Oct 1, 2027 (est.)Est. award date
Posted
Jul 1, 2026
Est. close date
Feb 16, 2027
Est. award date
Oct 1, 2027
Award floor
Not specified
Award ceiling
Not specified
Est. total funding
Not specified
Expected awards
Not specified
Cost sharing
Not required
Funding instrument
Cooperative Agreement
Opportunity category
Discretionary
Fiscal year
FY2027

Typical awards for this program (SAM.gov listing for ALN 93.233, not this notice): Grants: $45 to $2,585,120: $457,671. SBIR Phase I - $319,005; Phase II - up to $301,224; STTR Phase I - $128,047; Phase II – up to $654,527

Who can apply

  • State governments
  • County governments
  • City or township governments
  • Special district governments
  • Independent school districts
  • Public colleges & universities
  • Federally recognized tribal governments
  • Public & Indian housing authorities
  • Native American tribal organizations
  • 501(c)(3) nonprofits
  • Nonprofits without 501(c)(3) status
  • Private colleges & universities
  • For-profit organizations (not small businesses)
  • Small businesses
  • Others (see notice)

Additional information on eligibility (from the notice)

Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;Non-domestic (non-U.S.) Entities (Foreign Institutions).

A quick check against the listed applicant types — other requirements in the notice still apply.

Based on the published notice. Review the official notice for complete eligibility requirements.

What it funds

Official synopsis as published by the agency, formatted for readability.

The NIH intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications to develop and implement investigator-initiated multi-site clinical trials, including efficacy, effectiveness, pragmatic, and/or implementation research clinical trials. Applications that propose a large and/or complex clinical trial conducted at either a single site or at multiple locations but without physical clinical sites (e.g., decentralized or virtual trials) may also be eligible. Proposed trials must be relevant to the research mission of the participating ICs and meet the NIH definition of a clinical trial (see NOT-OD-15-015 and NOT-OD-26-032). The objective of the application is to present 1) the scientific rationale as well as a comprehensive scientific and operational plan for the trial, and 2) a comprehensive plan to provide overall project coordination, administration, data management, and biostatistical support for the clinical trial. 

Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop meaningful collaborations and responsive projects. This NOFO will utilize a bi-phasic (UG3/UH3), milestone-driven mechanism consisting of a start-up phase up to 2 years (UG3) and a full enrollment and clinical trial implementation phase up to 5 years (UH3), for a total award duration of up to 7 years. A UG3 project that meets its milestones will be administratively considered for transition to the UH3 award. Investigators with expertise and insights into this area are encouraged to begin to consider applying for this NOFO. 

How to apply

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Assistance Listings

What is an ALN?

Reported obligations under ALN 93.233

Historical data · not a prediction
FY24$105M
FY25$116M
FY26— est.
Source: SAM.gov Assistance Listing 93.233. Program-wide totals, not awards from this specific opportunity.

Who was funded under ALN 93.233

Historical data · not a prediction

Since October 1, 2023, 131 grant awards had funding actions under National Center on Sleep Disorders Research, with 40 sub-awards passed on to other organizations. These are program-wide awards, not awards from this specific notice.

Recipients, states, recent awards and sub-awards →Source: USAspending.gov.

Agency contact (as published)

National Heart, Lung, and Blood Institute (NHLBI)
NHLBIDCVSClinical@mail.nih.gov
Please contact via e-mail.

Quick answers

Is this opportunity open for applications yet?

Not yet. It is a forecast — an agency's advance notice of an expected opportunity. The agency estimates posting the full notice around November 16, 2026. Forecast details and dates can change.

Who is eligible to apply for this opportunity?

The official notice names these applicant types as eligible: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public colleges & universities, Federally recognized tribal governments, Public & Indian housing authorities, Native American tribal organizations, 501(c)(3) nonprofits, Nonprofits without 501(c)(3) status, Private colleges & universities and 3 more. Additional restrictions may apply; review the full notice.

How do I apply for this opportunity?

Applications are submitted through the official source, not through GrantsJunction. Open the official notice on Grants.gov (opportunity PAR-27-125), and review the full announcement and application package. Organizations applying through Grants.gov generally need an active SAM.gov registration and a Grants.gov account, which can take several weeks to set up.

Matched on shared Assistance Listings, agency, categories and eligible applicant types.