Translation and Implementation Science Research for Heart, Lung, Blood Diseases, and Sleep Disorders

Program objective

The National Heart, Lung, and Blood Institute (NHLBI) provides global leadership for a research, training, and education program to promote the prevention and treatment of heart, lung, and blood diseases and enhance the health of all individuals so that they can live longer and more fulfilling lives. The Center for Translation Research and Implementation Science (CTRIS) plans, fosters, and supports late-stage research to identify promising approaches for ensuring successful integration of evidence and evidence-based interventions within clinical and public health settings, such as health centers, worksites, schools, and communities in the United States and abroad. These approaches build on the successes in fundamental discovery science and early-stage translational research to ensure findings achieve maximal benefit for people and their communities. They also will help tackle new challenges in late-stage T4 translation research—the phase in the translational research pathway that leads to general knowledge about implementing evidence and evidence-based interventions—that helps turn discoveries into improved health. CTRIS is the strategic focal point within NHLBI to catalyze opportunities for rigorous dissemination and implementation research to advance the creation, evaluation, reporting, dissemination, sustained adoption, spread, and scale of evidence-based interventions for the prevention and treatment of heart, lung, blood, and sleep disorders. CTRIS is charged with integrating the domain expertise found in all NHLBI organizational units and leveraging the NIH-wide investments in dissemination and implementation research to accomplish its mission.

As published in the SAM.gov Assistance Listing.

Eligible applicants (program level)

• ✓Local
• ✓Not-for-Profit Organization
• ✓For-Profit Organization
• ✓Unrestricted by Individual Type
• ✓Nonprofit Organization

Local (includes State-designated lndian Tribes, excludes institutions of higher education and hospitals, Public nonprofit institution/organization (includes institutions of higher education and hospitals), Individual/Family, Small business (less than 500 employees), Private nonprofit institution/organization (includes institutions of higher education and hospitals). Any nonprofit organization engaged in biomedical research and institutions or companies organized for profit may apply for almost any kind of grant. Only domestic, non-profit, private or public institutions may apply for NRSA Institutional Research Training Grants. An individual may apply for an NRSA or, in some cases, for a research grant if adequate facilities to perform the research are available. SBIR grants can be awarded only to United States small business concerns (entities that are independently owned and operated for profit or owned by another small business that itself is independently owned and operated for profit, or owned by multiple venture capital operating companies, hedge funds, private equity firms, or any combination of these and have no more than 500 employees including affiliates). Primary employment (more than one-half time) of the principal investigator must be with the small business at the time of award and during the conduct of the proposed project. In both Phase I and Phase II, the research must be performed in the U.S. or its possessions except under rare and unique circumstances where foreign components are thoroughly justified and necessary to the overall completion of the project. To be eligible for funding, a grant application must be approved for scientific merit and program relevance by a scientific review group and a national advisory council. Normally, SBIR projects must be performed at least 67% by the applicant small business in Phase I and at least 50% of the Project in Phase II. STTR grants can be awarded only to United States small business concerns (entities that are independently owned and operated for profit and have no more than 500 employees) that formally collaborate with a university or other non-profit research institution in cooperative research and development. The principal investigator of an STTR award may be employed with either the small business concern or collaborating non-profit research institution as long as s/he has a formal appointment with or commitment to the applicant small business concern and is willing to devote at least 10% effort (1.2 calendar months) to the project. At least 40% of the project is to be performed by the small business concern and at least 30% by the non-profit research institution. In both Phase I and Phase II, the research must be performed in the U.S. and its possessions except under rare and unique circumstances where foreign components are thoroughly justified and necessary to the overall completion of the project.

Intended beneficiaries: Nonprofit Organization, Unrestricted by Individual Type and For-Profit Organization.

Program-level eligibility from SAM.gov. Each funding notice sets its own requirements.

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