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ForecastedResearch announcementOpportunity PAR-28-017

National Biomedical Research Centers (P50 Clinical Trial Optional)

National Institutes of Health · Department of Health and Human Services

At a glance

National Biomedical Research Centers (P50 Clinical Trial Optional) is a forecasted federal grant opportunity from the National Institutes of Health (Department of Health and Human Services). The agency's forecast estimates an application due date of January 25, 2027; forecast dates can change. Individual awards are listed as $7.96M – $11.4M, with about 2 awards expected. Applicant types listed as eligible include state governments, county governments, city or township governments, special district governments, independent school districts and 10 more. Cost sharing is not required. It is funded under Assistance Listing 93.351 (Research Infrastructure Programs).

Summary assembled from the official notice's fields. The official notice governs.

Key facts

  1. May 12, 2026Forecast posted
  2. Nov 25, 2026 (est.)Full notice expectednext date
  3. Jan 25, 2027 (est.)Application deadline
  4. Dec 1, 2027 (est.)Est. award date
Posted
May 12, 2026
Est. close date
Jan 25, 2027
Est. award date
Dec 1, 2027
Award floor
$7,955,376
Award ceiling
$11,405,967
Est. total funding
Not specified
Expected awards
2
Cost sharing
Not required
Funding instrument
Grant
Opportunity category
Discretionary
Fiscal year
FY2028

Who can apply

  • State governments
  • County governments
  • City or township governments
  • Special district governments
  • Independent school districts
  • Public colleges & universities
  • Federally recognized tribal governments
  • Public & Indian housing authorities
  • Native American tribal organizations
  • 501(c)(3) nonprofits
  • Nonprofits without 501(c)(3) status
  • Private colleges & universities
  • For-profit organizations (not small businesses)
  • Small businesses
  • Others (see notice)

Additional information on eligibility (from the notice)

Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;Non-domestic (non-U.S.) Entities (Foreign Institutions).

A quick check against the listed applicant types — other requirements in the notice still apply.

Based on the published notice. Review the official notice for complete eligibility requirements.

What it funds

Official synopsis as published by the agency, formatted for readability.

The National Biomedical Research Centers (NBRCs) are expected to provide scientific expertise, advanced equipment, infrastructure, and a range of well-characterized research models to researchers across the nation. Research at the NBRCs is supported by almost all NIH Institutes, as well as other federal agencies, including those that safeguard US national security interests. This NOFO emphasizes development of innovative human-based models and new technologies to reduce reliance on live research models. Applications must describe clear, actionable plans to reduce, refine, and replace whole-animal use by developing complementary and alternative approaches tailored to relevant use cases in biomedical research. Scientifically, the NBRCs function as centers of innovation in fundamental science as well as translational hubs that develop, refine, and test novel interventions for ultimate use in human patients. It is NIH’s intention that the NBRCs become leaders in the development and use of human-based approaches, including sophisticated in vitro and in silico models, known as New Approach Methodologies (NAMs). Clinical trials are allowed only as human-based NAMs, where applicable. This notice of funding opportunity (NOFO) is an open competition to increase opportunities for innovation, including NAMs research, at research centers with existing nonhuman primate colonies, and to further leverage existing capabilities in basic and translational research.

How to apply

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Assistance Listing

What is an ALN?

Reported obligations under ALN 93.351

Historical data · not a prediction
FY24$280M
FY25$284M
FY26$283M est.
Source: SAM.gov Assistance Listing 93.351. Program-wide totals, not awards from this specific opportunity.

Agency contact (as published)

Division of Comparative Medicine, Office of Research Infrastructure Programs
ORIPDCM@mail.nih.gov
301-451-2074

Quick answers

Is “National Biomedical Research Centers (P50 Clinical Trial Optional)” open for applications yet?

Not yet. It is a forecast — an agency's advance notice of an expected opportunity. The agency estimates posting the full notice around November 25, 2026. Forecast details and dates can change.

Who is eligible to apply for “National Biomedical Research Centers (P50 Clinical Trial Optional)”?

The official notice lists these applicant types as eligible: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public colleges & universities, Federally recognized tribal governments, Public & Indian housing authorities, Native American tribal organizations, 501(c)(3) nonprofits, Nonprofits without 501(c)(3) status, Private colleges & universities and 3 more. Additional restrictions may apply; review the full notice.

How much funding is available through “National Biomedical Research Centers (P50 Clinical Trial Optional)”?

Per the notice, individual awards are listed as $7.96m – $11.4m and the agency expects to make about 2 awards.

How do I apply for “National Biomedical Research Centers (P50 Clinical Trial Optional)”?

Applications are submitted through the official source, not through GrantsJunction. Open the official notice on Grants.gov (opportunity PAR-28-017), and review the full announcement and application package. Organizations applying through Grants.gov generally need an active SAM.gov registration and a Grants.gov account, which can take several weeks to set up.

Matched on shared Assistance Listings, agency, categories and eligible applicant types.