ForecastedResearch announcementOpportunity PAR-28-031

NIAMS Clinical Trial Implementation Cooperative Agreement

National Institutes of Health · Department of Health and Human Services

At a glance

NIAMS Clinical Trial Implementation Cooperative Agreement is a forecasted federal cooperative agreement opportunity from the National Institutes of Health (Department of Health and Human Services). The agency's forecast estimates an application due date of July 2, 2027; forecast dates can change. Individual awards are listed as from $250K, with about 4 awards expected. Applicant types listed as eligible include state governments, county governments, city or township governments, special district governments, independent school districts and 10 more. Cost sharing is not required. It is funded under Assistance Listing 93.846 (Arthritis, Musculoskeletal and Skin Diseases Research).

Summary assembled from the official notice's fields. The official notice governs.

Key facts

Jun 10, 2026Forecast posted
Nov 2, 2026 (est.)Full notice expectednext date
Jul 2, 2027 (est.)Application deadline
Apr 3, 2028 (est.)Est. award date

Posted: Jun 10, 2026
Est. close date: Jul 2, 2027
Est. award date: Apr 3, 2028
Award floor: $250,000
Award ceiling: Not specified
Est. total funding: Not specified
Expected awards: 4
Cost sharing: Not required
Funding instrument: Cooperative Agreement
Opportunity category: Discretionary
Fiscal year: FY2028

Who can apply

State governments
County governments
City or township governments
Special district governments
Independent school districts
Public colleges & universities
Federally recognized tribal governments
Public & Indian housing authorities
Native American tribal organizations
501(c)(3) nonprofits
Nonprofits without 501(c)(3) status
Private colleges & universities
For-profit organizations (not small businesses)
Small businesses
Others (see notice)

Additional information on eligibility (from the notice)

Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;Non-domestic (non-U.S.) Entities (Foreign Institutions).

Can your organization apply?

A quick check against the listed applicant types — other requirements in the notice still apply.

Based on the published notice. Review the official notice for complete eligibility requirements.

What it funds

Official synopsis as published by the agency, formatted for readability.

The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications for the Clinical Trial Cooperative Agreement Program within the mission areas of the institute. This Notice of Funding Opportunity (NOFO) solicits cooperative agreement applications for implementation of investigator-initiated, single or multi-site, interventional clinical trials (all trial phases). Investigators who have completed all necessary preparation (e.g., the trial design, protocol synopsis, data analysis plan, etc.) through other means may apply for a NIAMS Cooperative Agreement Clinical Trial. The first phase is designed to allow the investigators to prepare the final aspects needed to start the trial, (e.g., establishing the single IRB (sIRB), contracts and reliance agreements with sites, hiring of staff, etc.). Transition to the second phase to begin the trial is dependent upon completion of the phase 1 milestones proposed by the investigator and approved by NIAMS. Phase 1 projects that meet their milestones will be administratively considered by NIAMS and prioritized for transition to the second phase. NIAMS expects trials to be hypothesis-driven and have the potential for high clinical impact within the research mission of NIAMS.

How to apply

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Read the full announcement (NOFO)Eligibility, evaluation criteria, page limits and required attachments are in the full notice on Grants.gov. Open ↗
Confirm eligibility and fitCheck your organization type above; no cost sharing is required.
Register (or renew) in SAM.gov and get a UEIFree. New registrations can take several weeks; registrations must be renewed every year. Open ↗
Set up Grants.gov accessCreate a Grants.gov account and make sure someone has the Authorized Organization Representative (AOR) role. Open ↗
Watch for the full noticeThe agency estimates posting it around November 2, 2026. Save this grant to track changes.
Prepare narrative, budget and attachmentsFollow the notice's format exactly — page limits and required forms are common reasons applications are rejected.
Ask the agency contact any questions earlyNational Institute of Arthritis and Musculoskeletal and Skin Diseases · NIAMS_NOFOs@mail.nih.gov Open ↗
Submit before July 2, 2027Submit a few days early and keep your Grants.gov confirmation and validation emails.

Assistance Listing

What is an ALN?

93.846Arthritis, Musculoskeletal and Skin Diseases ResearchProgram →

Reported obligations under ALN 93.846

Historical data · not a prediction

FY20

$506M

FY21

$509M

FY22

$500M

FY23

$548M

FY24

$546M est.

FY25

$542M est.

Source: SAM.gov Assistance Listing 93.846. Program-wide totals, not awards from this specific opportunity.

Who was funded under ALN 93.846

Historical data · not a prediction

Since October 1, 2023, 3,169 grant awards had funding actions under Arthritis, Musculoskeletal and Skin Diseases Research, with 1,360 sub-awards passed on to other organizations. These are program-wide awards, not awards from this specific notice.

TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE$72.2M
REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE$60.4M
BRIGHAM & WOMENS HOSPITAL INC$54.4M
WASHINGTON UNIVERSITY, THE$48.9M
REGENTS OF THE UNIVERSITY OF MICHIGAN$48.1M

Recipients, states, recent awards and sub-awards →Source: USAspending.gov.

Agency contact (as published)

National Institute of Arthritis and Musculoskeletal and Skin Diseases
NIAMS_NOFOs@mail.nih.gov
Please contact via e-mail.

Quick answers

Is “NIAMS Clinical Trial Implementation Cooperative Agreement” open for applications yet?

Not yet. It is a forecast — an agency's advance notice of an expected opportunity. The agency estimates posting the full notice around November 2, 2026. Forecast details and dates can change.

Who is eligible to apply for “NIAMS Clinical Trial Implementation Cooperative Agreement”?

The official notice names these applicant types as eligible: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public colleges & universities, Federally recognized tribal governments, Public & Indian housing authorities, Native American tribal organizations, 501(c)(3) nonprofits, Nonprofits without 501(c)(3) status, Private colleges & universities and 3 more. Additional restrictions may apply; review the full notice.

How much funding is available through “NIAMS Clinical Trial Implementation Cooperative Agreement”?

Per the notice, individual awards are listed as from $250k and the agency expects to make about 4 awards.

How do I apply for “NIAMS Clinical Trial Implementation Cooperative Agreement”?

Applications are submitted through the official source, not through GrantsJunction. Open the official notice on Grants.gov (opportunity PAR-28-031), and review the full announcement and application package. Organizations applying through Grants.gov generally need an active SAM.gov registration and a Grants.gov account, which can take several weeks to set up.

Matched on shared Assistance Listings, agency, categories and eligible applicant types.

ForecastedResearchALN 93.846, 93.866