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OpenResearch announcementOpportunity RFA-DA-28-013

Neural Ensembles & Used Substances (NExUS) Collaboratory: Building a Multimodal Inventory of Cell Ensembles Encoding the Effects of Addictive Substances (U01 Clinical Trial Not Allowed)

National Institutes of Health · Department of Health and Human Services

At a glance

Neural Ensembles & Used Substances (NExUS) Collaboratory: Building a Multimodal Inventory of Cell Ensembles Encoding the Effects of Addictive Substances (U01 Clinical Trial Not Allowed) is an open federal cooperative agreement opportunity from the National Institutes of Health (Department of Health and Human Services). Applications are due February 8, 2027. Total estimated funding is $4M across about 4 awards. Applicant types listed as eligible include state governments, county governments, city or township governments, special district governments, independent school districts and 10 more. Cost sharing is not required. It is funded under Assistance Listing 93.279 (Drug Use and Addiction Research Programs).

Summary assembled from the official notice's fields. The official notice governs.

Key facts

  1. Oct 9, 2026Posted
  2. Feb 8, 2027Application deadlinenext date
  3. Jul 1, 2027 (est.)Est. award date
  4. Apr 9, 2027Archived
Posted
Oct 9, 2026
Close date
Feb 8, 2027
Archive date
Apr 9, 2027
Est. award date
Jul 1, 2027
Award floor
Not specified
Award ceiling
Not specified
Est. total funding
$4,000,000
Implied average award
$1,000,000 calculated
Expected awards
4
Cost sharing
Not required
Funding instrument
Cooperative Agreement
Opportunity category
Discretionary

Typical awards for this program (SAM.gov listing for ALN 93.279, not this notice): Range-$5,724 to $27,502,167, Average-$621,479

Implied average = estimated total funding ÷ expected number of awards, calculated by GrantsJunction. Actual awards vary.

Who can apply

  • State governments
  • County governments
  • City or township governments
  • Special district governments
  • Independent school districts
  • Public colleges & universities
  • Federally recognized tribal governments
  • Public & Indian housing authorities
  • Native American tribal organizations
  • 501(c)(3) nonprofits
  • Nonprofits without 501(c)(3) status
  • Private colleges & universities
  • For-profit organizations (not small businesses)
  • Small businesses
  • Others (see notice)

Additional information on eligibility (from the notice)

Refer to Section III. Eligibility Information in the NOFO for additional information on eligibilityForeign Organizations/International CollaborationsNon-domestic (non-U.S.) Entities (Foreign Organizations) are eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.NIH will no longer issue awards (i.e., new, renewal, or non-competing continuation) to domestic or foreign entities that involve foreign subawards/subcontracts. All NIH-funded research involving foreign subawards/subcontracts must be submitted in response to a NOFO that is specifically designated for funded international collaborations. See NIH Grants Policy Statement 16.8 Collaborative International Research Awards.Applications involving foreign subawards/subcontracts submitted in response to this NOFO will be deemed noncompliant and will not be considered for funding. This policy applies to all monetary international collaborations resulting in foreign subawards/subcontracts, however, it does not preclude unfunded international collaborations or foreign components, funding for foreign consultants, or procurement of unique equipment or supplies from foreign vendors.

A quick check against the listed applicant types — other requirements in the notice still apply.

Based on the published notice. Review the official notice for complete eligibility requirements.

What it funds

Official synopsis as published by the agency, formatted for readability.

The National Institute on Drug Abuse (NIDA) invites applications to renew and expand the Collaboratory on Neural Ensembles and Used Substances (NExUS).

NExUS is a collaborative research program to decode how substance use experiences and addictive neurobehavioral states are represented in the brain at the level of cell populations. 

This funding opportunity seeks applications that propose systematic and scalable methods to identify, map, and analyze groups of neurons that respond to used substances. The goal is to create a comprehensive, multimodal database and use it to test hypotheses about how specific neural population activity patterns relate to behavioral states associated with substance use and substance use disorders (SUD), including intoxication, craving, and dependence.
 

Full announcement & documents

The full announcement has the complete rules — page limits, required attachments, evaluation criteria and any letter-of-intent dates. Files download directly from Grants.gov.

How to apply

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Assistance Listing

What is an ALN?

Reported obligations under ALN 93.279

Historical data · not a prediction
FY24$1.25B
FY25$1.34B
FY26$20.2M est.
Source: SAM.gov Assistance Listing 93.279. Program-wide totals, not awards from this specific opportunity.

Who was funded under ALN 93.279

Historical data · not a prediction

Since October 1, 2023, 5,882 grant awards had funding actions under Drug Use and Addiction Research Programs, with 5,205 sub-awards passed on to other organizations. These are program-wide awards, not awards from this specific notice.

  1. YALE UNIV$178M
  2. THE JOHNS HOPKINS UNIVERSITY$173M
  3. UNIVERSITY OF CALIFORNIA, SAN DIEGO$172M
  4. UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION$127M
  5. REGENTS OF THE UNIVERSITY OF MICHIGAN$106M
Recipients, states, recent awards and sub-awards →Source: USAspending.gov.

Agency contact (as published)

National Institutes of Health
INBranch_NIDA@nih.gov
301-402-2541

Changes we detected

  • Oct 9, 2026: Estimated total funding changed
  • Oct 9, 2026: Award ceiling changed
  • Oct 9, 2026: Close date changed
  • Oct 9, 2026: Title changed

Quick answers

When is the deadline for this opportunity?

According to the official notice, applications are due February 8, 2027. Confirm the deadline and submission time on Grants.gov before applying.

Who is eligible to apply for this opportunity?

The official notice names these applicant types as eligible: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public colleges & universities, Federally recognized tribal governments, Public & Indian housing authorities, Native American tribal organizations, 501(c)(3) nonprofits, Nonprofits without 501(c)(3) status, Private colleges & universities and 3 more. Additional restrictions may apply; review the full notice.

How much funding is available through this opportunity?

Per the notice, total estimated program funding is $4,000,000 and the agency expects to make about 4 awards.

How do I apply for this opportunity?

Applications are submitted through the official source, not through GrantsJunction. Open the official notice on Grants.gov (opportunity RFA-DA-28-013), and review the full announcement and application package. Organizations applying through Grants.gov generally need an active SAM.gov registration and a Grants.gov account, which can take several weeks to set up.

Matched on shared Assistance Listings, agency, categories and eligible applicant types.