ForecastedResearch announcementOpportunity RFA-DA-28-001

Single Cell Opioid Responses in the Context of HIV (SCORCH) Program: Phase 2

National Institutes of Health · Department of Health and Human Services

At a glance

Single Cell Opioid Responses in the Context of HIV (SCORCH) Program: Phase 2 is a forecasted federal cooperative agreement opportunity from the National Institutes of Health (Department of Health and Human Services). The agency's forecast estimates an application due date of June 8, 2027; forecast dates can change. Individual awards are listed as up to $1M, with about 8 awards expected and $5M in total estimated funding. Applicant types listed as eligible include state governments, county governments, city or township governments, special district governments, independent school districts and 10 more. Cost sharing is not required. It is funded under Assistance Listing 93.279 (Drug Use and Addiction Research Programs).

Summary assembled from the official notice's fields. The official notice governs.

Key facts

Aug 20, 2026Forecast posted
Feb 1, 2027 (est.)Full notice expectednext date
Jun 8, 2027 (est.)Application deadline
Apr 1, 2028 (est.)Est. award date

Posted: Aug 20, 2026
Est. close date: Jun 8, 2027
Est. award date: Apr 1, 2028
Award floor: Not specified
Award ceiling: $1,000,000
Est. total funding: $5,000,000
Expected awards: 8
Cost sharing: Not required
Funding instrument: Cooperative Agreement
Opportunity category: Discretionary
Fiscal year: FY2028

Who can apply

State governments
County governments
City or township governments
Special district governments
Independent school districts
Public colleges & universities
Federally recognized tribal governments
Public & Indian housing authorities
Native American tribal organizations
501(c)(3) nonprofits
Nonprofits without 501(c)(3) status
Private colleges & universities
For-profit organizations (not small businesses)
Small businesses
Others (see notice)

Additional information on eligibility (from the notice)

Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;

Can your organization apply?

A quick check against the listed applicant types — other requirements in the notice still apply.

Based on the published notice. Review the official notice for complete eligibility requirements.

What it funds

Official synopsis as published by the agency, formatted for readability.

NIDA seeks to further advance its mission in the area of single cell biology. Since 2020, the NIDA-funded Single Cell Opioid Responses in the Context of HIV (SCORCH) consortium has generated single-nucleus datasets from human and animal postmortem brain tissue under conditions of HIV infection, antiretroviral therapy (ART), and/or substance exposure (e.g. opioids, cocaine, methamphetamine, and cannabinoids). Building on this Phase 1 foundation, NIDA will encourage research addressing critical questions on Substance Use Disorder (SUD) and interactions with HIV disease progression at the subcellular, cellular, or circuit levels in the Central Nervous System (CNS). Many new cutting-edge single cell approaches (e.g. interrogation of RNA splicing, non-coding RNAs, epigenomic or proteomic features, subcellular or synaptic localization and function, spatial interactions, cell-cell communication, or cellular connectivity) now enable novel hypothesis-generating studies. Along with data mining studies to identify candidate mechanisms or targets contributing to HIV/SUD interactions and hypothesis-driven studies to assess functional significance, we expect SCORCH Phase 2 to significantly advance our mechanistic understanding of SUDs and HIV in the CNS and identify targets for novel therapies. Grant authorities that allow NIDA to forecast this opportunity are 42 U.S.C. §§ 241 and 284

How to apply

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Read the full announcement (NOFO)Eligibility, evaluation criteria, page limits and required attachments are in the full notice on Grants.gov. Open ↗
Confirm eligibility and fitCheck your organization type above; no cost sharing is required.
Register (or renew) in SAM.gov and get a UEIFree. New registrations can take several weeks; registrations must be renewed every year. Open ↗
Set up Grants.gov accessCreate a Grants.gov account and make sure someone has the Authorized Organization Representative (AOR) role. Open ↗
Watch for the full noticeThe agency estimates posting it around February 1, 2027. Save this grant to track changes.
Prepare narrative, budget and attachmentsFollow the notice's format exactly — page limits and required forms are common reasons applications are rejected.
Ask the agency contact any questions earlyNational Institute on Drug Abuse (NIDA) · NIDA_GED_Program@nida.nih.gov Open ↗
Submit before June 8, 2027Submit a few days early and keep your Grants.gov confirmation and validation emails.

Assistance Listing

What is an ALN?

93.279Drug Use and Addiction Research ProgramsProgram →

Reported obligations under ALN 93.279

Historical data · not a prediction

FY24

$1.25B

FY25

$1.34B

FY26

$20.2M est.

Source: SAM.gov Assistance Listing 93.279. Program-wide totals, not awards from this specific opportunity.

Who was funded under ALN 93.279

Historical data · not a prediction

Since October 1, 2023, 5,882 grant awards had funding actions under Drug Use and Addiction Research Programs, with 5,205 sub-awards passed on to other organizations. These are program-wide awards, not awards from this specific notice.

YALE UNIV$178M
THE JOHNS HOPKINS UNIVERSITY$173M
UNIVERSITY OF CALIFORNIA, SAN DIEGO$172M
UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION$127M
REGENTS OF THE UNIVERSITY OF MICHIGAN$106M

Recipients, states, recent awards and sub-awards →Source: USAspending.gov.

Agency contact (as published)

National Institute on Drug Abuse (NIDA)
NIDA_GED_Program@nida.nih.gov
Please contact via e-mail.

Quick answers

Is “Single Cell Opioid Responses in the Context of HIV (SCORCH) Program: Phase 2” open for applications yet?

Not yet. It is a forecast — an agency's advance notice of an expected opportunity. The agency estimates posting the full notice around February 1, 2027. Forecast details and dates can change.

Who is eligible to apply for “Single Cell Opioid Responses in the Context of HIV (SCORCH) Program: Phase 2”?

The official notice names these applicant types as eligible: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public colleges & universities, Federally recognized tribal governments, Public & Indian housing authorities, Native American tribal organizations, 501(c)(3) nonprofits, Nonprofits without 501(c)(3) status, Private colleges & universities and 3 more. Additional restrictions may apply; review the full notice.

How much funding is available through “Single Cell Opioid Responses in the Context of HIV (SCORCH) Program: Phase 2”?

Per the notice, individual awards are listed as up to $1m, total estimated program funding is $5,000,000 and the agency expects to make about 8 awards.

How do I apply for “Single Cell Opioid Responses in the Context of HIV (SCORCH) Program: Phase 2”?

Applications are submitted through the official source, not through GrantsJunction. Open the official notice on Grants.gov (opportunity RFA-DA-28-001), and review the full announcement and application package. Organizations applying through Grants.gov generally need an active SAM.gov registration and a Grants.gov account, which can take several weeks to set up.

Matched on shared Assistance Listings, agency, categories and eligible applicant types.

OpenResearchALN 93.213, 93.273…