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ForecastedResearch announcementOpportunity RFA-DK-28-115

Single Source Competition for Continuation of Understanding and Targeting the Pathophysiology of Youth-Onset Type 2 Diabetes Clinical Centers (U01 Clinical Trial Not Allowed)

National Institutes of Health · Department of Health and Human Services

At a glance

Single Source Competition for Continuation of Understanding and Targeting the Pathophysiology of Youth-Onset Type 2 Diabetes Clinical Centers (U01 Clinical Trial Not Allowed) is a forecasted federal cooperative agreement opportunity from the National Institutes of Health (Department of Health and Human Services). The agency's forecast estimates an application due date of March 10, 2027; forecast dates can change. Total estimated funding is $35M across about 1 awards. Applicant types listed as eligible include others (see notice). Cost sharing is not required. It is funded under Assistance Listing 93.847 (Diabetes, Digestive, and Kidney Diseases Extramural Research).

Summary assembled from the official notice's fields. The official notice governs.

Key facts

  1. Aug 4, 2026Forecast posted
  2. Feb 2, 2027 (est.)Full notice expectednext date
  3. Mar 10, 2027 (est.)Application deadline
  4. Nov 1, 2027 (est.)Est. award date
Posted
Aug 4, 2026
Est. close date
Mar 10, 2027
Est. award date
Nov 1, 2027
Award floor
Not specified
Award ceiling
Not specified
Est. total funding
$35,000,000
Implied average award
$35,000,000 calculated
Expected awards
1
Cost sharing
Not required
Funding instrument
Cooperative Agreement
Opportunity category
Discretionary
Fiscal year
FY2028

Typical awards for this program (SAM.gov listing for ALN 93.847, not this notice): Project Grants: Range of $1,300 to $10,834,000; $418,000 average NRSAs: Range of $2,500 to $869,000; $116,000 average SBIR: Range of $6,500 to $2,074,000; $585,000 average

Implied average = estimated total funding ÷ expected number of awards, calculated by GrantsJunction. Actual awards vary.

Who can apply

  • Others (see notice)

Additional information on eligibility (from the notice)

This is a Single Source competition that will invite application(s) from eligible organization(s) to apply. Please see Eligibility Section for additional information. In accordance with NIH standard peer-review processes, the application(s) will be peer-reviewed, and only meritorious application(s) will be considered for funding.

A quick check against the listed applicant types — other requirements in the notice still apply.

Based on the published notice. Review the official notice for complete eligibility requirements.

What it funds

Official synopsis as published by the agency, formatted for readability.

The DISCOVERY of Risk Factors for Type 2 Diabetes in Youth Study is a multi-center longitudinal consortium conducted across 19 clinical sites to identify risk factors and biological mechanisms driving progression to youth-onset type 2 diabetes. The study is actively recruiting and following early pubertal youth at high risk for the disease with longitudinal follow-up currently underway. The current Biostatistics Research Center (BRC) serves as the consortium's central coordinating center, managing protocol implementation, data management, quality assurance, statistical design and analysis, and inter-site and consortium-wide coordination.  The BRC has established the robust infrastructure and standardized processes required to support the study and preserve the integrity of the longitudinal dataset. 

The purpose of this single-source solicitation is to support completion of the scientific objectives of the ongoing DISCOVERY clinical consortium.

How to apply

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Assistance Listing

What is an ALN?

Reported obligations under ALN 93.847

Historical data · not a prediction
FY24$1.97B
FY25$2.04B
FY26$111M est.
Source: SAM.gov Assistance Listing 93.847. Program-wide totals, not awards from this specific opportunity.

Who was funded under ALN 93.847

Historical data · not a prediction

Since October 1, 2023, 8,539 grant awards had funding actions under Diabetes, Digestive, and Kidney Diseases Extramural Research, with 6,760 sub-awards passed on to other organizations. These are program-wide awards, not awards from this specific notice.

  1. REGENTS OF THE UNIVERSITY OF MICHIGAN$205M
  2. TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE$182M
  3. UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION$143M
  4. WASHINGTON UNIVERSITY, THE$138M
  5. REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE$136M
Recipients, states, recent awards and sub-awards →Source: USAspending.gov.

Agency contact (as published)

Division of Diabetes, Endocrinology and Metabolic Diseases
NIDDK_DEM@nih.gov
NIDDK_DEM@nih.gov

Quick answers

Is this opportunity open for applications yet?

Not yet. It is a forecast — an agency's advance notice of an expected opportunity. The agency estimates posting the full notice around February 2, 2027. Forecast details and dates can change.

Who is eligible to apply for this opportunity?

The official notice names these applicant types as eligible: Others (see notice). Additional restrictions may apply; review the full notice.

How much funding is available through this opportunity?

Per the notice, total estimated program funding is $35,000,000 and the agency expects to make about 1 awards.

How do I apply for this opportunity?

Applications are submitted through the official source, not through GrantsJunction. Open the official notice on Grants.gov (opportunity RFA-DK-28-115), and review the full announcement and application package. Organizations applying through Grants.gov generally need an active SAM.gov registration and a Grants.gov account, which can take several weeks to set up.

Matched on shared Assistance Listings, agency, categories and eligible applicant types.