OpenOpportunity RFA-HG-27-013

GREGoRi Innovation Projects (U01 Clinical Trial Optional)

National Institutes of Health · Department of Health and Human Services

At a glance

GREGoRi Innovation Projects (U01 Clinical Trial Optional) is an open federal cooperative agreement opportunity from the National Institutes of Health (Department of Health and Human Services). Applications are due October 30, 2026. Individual awards are listed as $3 – $500K, with about 10 awards expected and $7.5M in total estimated funding. Applicant types listed as eligible include state governments, county governments, city or township governments, special district governments, independent school districts and 10 more. Cost sharing is not required. It is funded under Assistance Listing 93.172 (Human Genome Research).

Summary assembled from the official notice's fields. The official notice governs.

Key facts

Posted: Jun 18, 2026
Close date: Oct 30, 2026
Archive date: Dec 9, 2026
Est. award date: Jul 6, 2026
Award floor: $3
Award ceiling: $500,000
Est. total funding: $7,500,000
Expected awards: 10
Cost sharing: Not required
Funding instrument: Cooperative Agreement
Opportunity category: Discretionary

Who can apply

State governments
County governments
City or township governments
Special district governments
Independent school districts
Public colleges & universities
Federally recognized tribal governments
Public & Indian housing authorities
Native American tribal organizations
501(c)(3) nonprofits
Nonprofits without 501(c)(3) status
Private colleges & universities
For-profit organizations (not small businesses)
Small businesses
Others (see notice)

Additional information on eligibility (from the notice)

Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International Collaborations:Non-domestic (non-U.S.) Entities (Foreign Organizations) are eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

Based on the published notice. Review the official notice for complete eligibility requirements.

What it funds

Official synopsis as published by the agency, formatted for readability.

The Genomics Research to Elucidate the Genetics of Rare Diseases:innovation (GREGoRi) initiative seeks to accelerate a paradigm shift in rare disease diagnosis by reimagining the tools, molecular technologies and analytical approaches used to identify the causal gene(s) and/or variant(s) underlying rare genetic disorders. This Notice of Funding Opportunity is intended to stimulate the development and testing of highly innovative experimental or computational approaches for rare disease diagnosis, that have the potential to make transformative improvements to the current state of the art.

Assistance Listing

What is an ALN?

93.172Human Genome ResearchProgram →

Reported obligations under ALN 93.172

Historical data · not a prediction

FY24

$453M

FY25

$424M

FY26

$9.99M est.

Source: SAM.gov Assistance Listing 93.172. Program-wide totals, not awards from this specific opportunity.

Agency contact (as published)

National Institutes of Health
nhgri-gregor@mail.nih.gov
301-402-2541

Quick answers

When is the deadline for “GREGoRi Innovation Projects (U01 Clinical Trial Optional)”?

According to the official notice, applications are due October 30, 2026. Confirm the deadline and submission time on Grants.gov before applying.

Who is eligible to apply for “GREGoRi Innovation Projects (U01 Clinical Trial Optional)”?

The official notice lists these applicant types as eligible: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public colleges & universities, Federally recognized tribal governments, Public & Indian housing authorities, Native American tribal organizations, 501(c)(3) nonprofits, Nonprofits without 501(c)(3) status, Private colleges & universities and 3 more. Additional restrictions may apply; review the full notice.

How much funding is available through “GREGoRi Innovation Projects (U01 Clinical Trial Optional)”?

Per the notice, individual awards are listed as $3 – $500k, total estimated program funding is $7,500,000 and the agency expects to make about 10 awards.

How do I apply for “GREGoRi Innovation Projects (U01 Clinical Trial Optional)”?

Applications are submitted through the official source, not through GrantsJunction. Open the official notice on Grants.gov (opportunity RFA-HG-27-013), and review the full announcement and application package. Organizations applying through Grants.gov generally need an active SAM.gov registration and a Grants.gov account, which can take several weeks to set up.

Matched on shared Assistance Listings, agency, categories and eligible applicant types.

ForecastedALN 93.172