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ForecastedOpportunity RFA-NS-26-002

Investigate Novel Therapeutic Interventions and Testing Strategies for Neurological Disorders Including to Treat, Modify and Prevent the Development of Epilepsy (U24 Clinical Trial Not Allowed)

National Institutes of Health · Department of Health and Human Services

At a glance

Investigate Novel Therapeutic Interventions and Testing Strategies for Neurological Disorders Including to Treat, Modify and Prevent the Development of Epilepsy (U24 Clinical Trial Not Allowed) is a forecasted federal cooperative agreement opportunity from the National Institutes of Health (Department of Health and Human Services). The agency's forecast estimates an application due date of February 20, 2026; forecast dates can change. Individual awards are listed as $3.5M – $4M, with about 1 award expected and $6.2M in total estimated funding. Applicant types listed as eligible include state governments, county governments, city or township governments, special district governments, independent school districts and 10 more. Cost sharing is not required. It is funded under Assistance Listing 93.853 (Extramural Research Programs in the Neurosciences and Neurological Disorders).

Summary assembled from the official notice's fields. The official notice governs.

Key facts

Posted
Sep 23, 2025
Est. close date
Feb 20, 2026
Est. award date
Nov 2, 2026
Award floor
$3,500,000
Award ceiling
$4,000,000
Est. total funding
$6,200,000
Expected awards
1
Cost sharing
Not required
Funding instrument
Cooperative Agreement
Opportunity category
Discretionary
Fiscal year
FY2027

Who can apply

  • State governments
  • County governments
  • City or township governments
  • Special district governments
  • Independent school districts
  • Public colleges & universities
  • Federally recognized tribal governments
  • Public & Indian housing authorities
  • Native American tribal organizations
  • 501(c)(3) nonprofits
  • Nonprofits without 501(c)(3) status
  • Private colleges & universities
  • For-profit organizations (not small businesses)
  • Small businesses
  • Others (see notice)

Additional information on eligibility (from the notice)

Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;Non-domestic (non-U.S.) Entities (Foreign Institutions).

Based on the published notice. Review the official notice for complete eligibility requirements.

What it funds

Official synopsis as published by the agency, formatted for readability.

The National Institute of Neurological Disorders and Stroke (NINDS) intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications to investigate novel therapeutic interventions and testing strategies for neurological disorders including to treat, modify, and prevent epilepsy. This research should include various intervention modalities and testing strategies. Investigators should consider testing strategies for the development and validation of human-focused testing approaches. Investigators with expertise and insights into preclinical therapy testing and model development are encouraged to consider applying for this new NOFO. 

Assistance Listing

What is an ALN?

Reported obligations under ALN 93.853

Historical data · not a prediction
FY24$2.36B
FY25$2.35B
FY26— est.
Source: SAM.gov Assistance Listing 93.853. Program-wide totals, not awards from this specific opportunity.

Agency contact (as published)

Brian Klein, PhD
brian.klein@nih.gov
(301) 496-0981

Quick answers

Is this opportunity open for applications yet?

Not yet. It is a forecast — an agency's advance notice of an expected opportunity. The agency estimates posting the full notice around December 19, 2025. Forecast details and dates can change.

Who is eligible to apply for this opportunity?

The official notice lists these applicant types as eligible: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public colleges & universities, Federally recognized tribal governments, Public & Indian housing authorities, Native American tribal organizations, 501(c)(3) nonprofits, Nonprofits without 501(c)(3) status, Private colleges & universities and 3 more. Additional restrictions may apply; review the full notice.

How much funding is available through this opportunity?

Per the notice, individual awards are listed as $3.5m – $4m, total estimated program funding is $6,200,000 and the agency expects to make about 1 awards.

How do I apply for this opportunity?

Applications are submitted through the official source, not through GrantsJunction. Open the official notice on Grants.gov (opportunity RFA-NS-26-002), and review the full announcement and application package. Organizations applying through Grants.gov generally need an active SAM.gov registration and a Grants.gov account, which can take several weeks to set up.

Matched on shared Assistance Listings, agency, categories and eligible applicant types.