ForecastedResearch announcementOpportunity RFA-OD-26-006

High-Priority Research in Tobacco Regulatory Science (Clinical Trial Optional)

National Institutes of Health · Department of Health and Human Services

At a glance

High-Priority Research in Tobacco Regulatory Science (Clinical Trial Optional) is a forecasted federal grant opportunity from the National Institutes of Health (Department of Health and Human Services). The agency's forecast estimates an application due date of May 4, 2026; forecast dates can change. Individual awards are listed as up to $500K, with about 8 awards expected and $7M in total estimated funding. Applicant types listed as eligible include state governments, county governments, city or township governments, special district governments, independent school districts and 10 more. Cost sharing is not required. It is funded under Assistance Listing 93.077 (Family Smoking Prevention and Tobacco Control Act Regulatory Research).

Summary assembled from the official notice's fields. The official notice governs.

Key facts

Sep 9, 2025Forecast posted
Jan 14, 2026 (est.)Full notice expected
May 4, 2026 (est.)Application deadline
Dec 4, 2026 (est.)Est. award datenext date

Posted: Sep 9, 2025
Est. close date: May 4, 2026
Est. award date: Dec 4, 2026
Award floor: Not specified
Award ceiling: $500,000
Est. total funding: $7,000,000
Expected awards: 8
Cost sharing: Not required
Funding instrument: Grant
Opportunity category: Discretionary
Fiscal year: FY2027

Who can apply

State governments
County governments
City or township governments
Special district governments
Independent school districts
Public colleges & universities
Federally recognized tribal governments
Public & Indian housing authorities
Native American tribal organizations
501(c)(3) nonprofits
Nonprofits without 501(c)(3) status
Private colleges & universities
For-profit organizations (not small businesses)
Small businesses
Others (see notice)

Additional information on eligibility (from the notice)

Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;Non-domestic (non-U.S.) Entities (Foreign Institutions). Non-domestic (non-U.S.) components of U.S. OrganizationsForeign components, as defined in the NIH Grants Policy Statement

Can your organization apply?

A quick check against the listed applicant types — other requirements in the notice still apply.

Based on the published notice. Review the official notice for complete eligibility requirements.

What it funds

Official synopsis as published by the agency, formatted for readability.

The Tobacco Regulatory Science Program, participating NIH Institutes and Centers (ICs), and the United States Food and Drug Administration (FDA) Center for Tobacco Products (CTP) intend to issue a Notice of Funding Opportunity (NOFO) soliciting applications for High-Priority Research Projects in Tobacco Regulatory Science (Clinical Trial Optional).

The FDA and NIH share an interest in supporting research that could inform FDA's tobacco regulatory authorities. High-priority research encouraged by this NOFO is expected to provide additional scientific data to the research base to inform the regulation of tobacco products to protect public health. Although a vast and sound science base exists related to the Family Smoking Prevention and Tobacco Control Act (FSPTCA), Public Law 111-31, the NOFO will seek high-priority research that will provide additional science for the FDA to consider as it implements the FSPTCA.

In order to be considered responsive, research must (1) be within the regulatory authority of FDA CTP, (2) address one or more of the following topics: Addiction, Behavior, Communications, Health Effects, Product Composition and Design, and/or Toxicity; and (3) address all components within the subtopic(s) of the selected topic(s).

Awards will be administered by NIH using funds made available through FDA CTP and the FSPTCA. TRSP is authorized to forecast this opportunity under The Public Health Service Act and the FSPTCA, Public Law 111-31, 42 US Code 300u-3.

How to apply

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Read the full announcement (NOFO)Eligibility, evaluation criteria, page limits and required attachments are in the full notice on Grants.gov. Open ↗
Confirm eligibility and fitCheck your organization type above; no cost sharing is required.
Register (or renew) in SAM.gov and get a UEIFree. New registrations can take several weeks; registrations must be renewed every year. Open ↗
Set up Grants.gov accessCreate a Grants.gov account and make sure someone has the Authorized Organization Representative (AOR) role. Open ↗
Watch for the full noticeThe agency estimates posting it around January 14, 2026. Save this grant to track changes.
Prepare narrative, budget and attachmentsFollow the notice's format exactly — page limits and required forms are common reasons applications are rejected.
Ask the agency contact any questions earlyErik Rodriquez, Ph.D., M.P.H. · TRSP@nih.gov Open ↗
Submit before May 4, 2026Submit a few days early and keep your Grants.gov confirmation and validation emails.

Assistance Listing

What is an ALN?

93.077Family Smoking Prevention and Tobacco Control Act Regulatory ResearchProgram →

Reported obligations under ALN 93.077

Historical data · not a prediction

FY20

$80.4M

FY21

$73.8M

FY22

$67.3M

FY23

$59.3M

FY24

$59.1M est.

FY25

$54M est.

Source: SAM.gov Assistance Listing 93.077. Program-wide totals, not awards from this specific opportunity.

Agency contact (as published)

Erik Rodriquez, Ph.D., M.P.H.
TRSP@nih.gov
301-827-2830

Quick answers

Is “High-Priority Research in Tobacco Regulatory Science (Clinical Trial Optional)” open for applications yet?

Not yet. It is a forecast — an agency's advance notice of an expected opportunity. The agency estimates posting the full notice around January 14, 2026. Forecast details and dates can change.

Who is eligible to apply for “High-Priority Research in Tobacco Regulatory Science (Clinical Trial Optional)”?

The official notice lists these applicant types as eligible: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public colleges & universities, Federally recognized tribal governments, Public & Indian housing authorities, Native American tribal organizations, 501(c)(3) nonprofits, Nonprofits without 501(c)(3) status, Private colleges & universities and 3 more. Additional restrictions may apply; review the full notice.

How much funding is available through “High-Priority Research in Tobacco Regulatory Science (Clinical Trial Optional)”?

Per the notice, individual awards are listed as up to $500k, total estimated program funding is $7,000,000 and the agency expects to make about 8 awards.

How do I apply for “High-Priority Research in Tobacco Regulatory Science (Clinical Trial Optional)”?

Applications are submitted through the official source, not through GrantsJunction. Open the official notice on Grants.gov (opportunity RFA-OD-26-006), and review the full announcement and application package. Organizations applying through Grants.gov generally need an active SAM.gov registration and a Grants.gov account, which can take several weeks to set up.

Matched on shared Assistance Listings, agency, categories and eligible applicant types.

ForecastedResearchALN 93.077