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ForecastedOpportunity RFA-OH-27-049

NIOSH Centers of Excellence for Total Worker Health® (U19)

Centers for Disease Control and Prevention - ERA · Department of Health and Human Services

At a glance

NIOSH Centers of Excellence for Total Worker Health® (U19) is a forecasted federal cooperative agreement opportunity from the Centers for Disease Control and Prevention - ERA (Department of Health and Human Services). The agency's forecast estimates an application due date of February 26, 2027; forecast dates can change. Individual awards are listed as $500K – $1.4M, with about 10 awards expected and $58.5M in total estimated funding. The notice is unrestricted by applicant type, subject to any clarifications in the notice. Cost sharing is not required. It is funded under Assistance Listing 93.262 (Occupational Safety and Health Program).

Summary assembled from the official notice's fields. The official notice governs.

Key facts

Posted
Jul 28, 2026
Est. close date
Feb 26, 2027
Est. award date
Aug 2, 2027
Award floor
$500,000
Award ceiling
$1,400,000
Est. total funding
$58,500,000
Expected awards
10
Cost sharing
Not required
Funding instrument
Cooperative Agreement
Opportunity category
Discretionary
Fiscal year
FY2027

Who can apply

  • State governments
  • County governments
  • City or township governments
  • Special district governments
  • Independent school districts
  • Public colleges & universities
  • Federally recognized tribal governments
  • Public & Indian housing authorities
  • Native American tribal organizations
  • 501(c)(3) nonprofits
  • Nonprofits without 501(c)(3) status
  • Private colleges & universities
  • For-profit organizations (not small businesses)
  • Small businesses
  • Unrestricted (any entity type)

Additional information on eligibility (from the notice)

Non-domestic (non-U.S.) Entities (Foreign Institutions) are not eligible to apply. Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply. Foreign components, as defined in the HHS Grants Policy Statement, are not allowed.

Based on the published notice. Review the official notice for complete eligibility requirements.

What it funds

Official synopsis as published by the agency, formatted for readability.

PURPOSE
NIOSH intends to support the Centers of Excellence in Total Worker Health® (TWH). These Centers will conduct rigorous research and translation activities to prevent harmful exposures, improve working conditions, and advance worker well-being. The Centers will develop practical, scalable solutions for employers and workers. All projects must use the NIOSH Worker Well-Being Questionnaire (WellBQ) and share data with the HERO Worker Well-Being Clearinghouse. Large Research Projects require economic evaluation. 

PRIORITY AREAS
• High-risk occupations: First responders, vehicle mechanics, and technicians, with emphasis on occupational exposures, related health risks, and prevention strategies
• Young workers, SMEs 
• Chronic disease
• Mental health, stress
• Substance use disorder
• Artificial intelligence (AI), digital technologies

This is a multi-component NOFO.

COMPONENT STRUCTURE
Percentages indicate maximum share of total budget.

Overall Component (Required)
Provides Center leadership and integration. Applicants should show strong coordination, scientific direction, and alignment across projects.

Administration, Evaluation, and Emerging Issues Core (Required; up to 15%)
Supports management and Center-wide evaluation. Applicants should describe oversight, data governance, and quality assurance.Optional activities include emerging issues and shared research resources.

Outreach, Dissemination, and Impact Core (Required; up to 15%)
Supports communication, worker/employer engagement, training, translation, implementation, and dissemination strategies.

Research Projects (Required; about 60 to 70%)
Includes all research activities. Applicants may propose a mix of projects. Research project distinctions are based on scope and complexity rather than cost. Projects should demonstrate scientific rigor and potential for sustained impact.

  • Small Research Projects (Required; at least one project; up to 3 years)
    Exploratory, feasibility, early-stage intervention, surveillance, or measurement studies.
    Priority areas: high-risk occupations, young workers, SMEs.
    Should show innovation and potential to expand. 
  • Large Research Projects (Required; at least one project; up to 5 years)
    Multiyear etiologic, mechanistic, intervention, or translational studies.
    Priority areas: chronic disease, mental health, substance use disorder. 
    Economic evaluation is required. Projects should include strong design and analytic plans. 
  • Pilot/Feasibility Program (Optional; 12–18 months) 
    Short-term studies generating preliminary data or testing AI/digital technology approaches.

Assistance Listing

What is an ALN?

Reported obligations under ALN 93.262

Historical data · not a prediction
FY24$131M
FY25$128M
FY26$113M est.
Source: SAM.gov Assistance Listing 93.262. Program-wide totals, not awards from this specific opportunity.

Agency contact (as published)

Maria Lioce, MD, Scientific Program Official
MLioce@cdc.gov
404-498-2575

Quick answers

Is “NIOSH Centers of Excellence for Total Worker Health® (U19)” open for applications yet?

Not yet. It is a forecast — an agency's advance notice of an expected opportunity. The agency estimates posting the full notice around November 16, 2026. Forecast details and dates can change.

Who is eligible to apply for “NIOSH Centers of Excellence for Total Worker Health® (U19)”?

The notice lists eligibility as unrestricted — open to any type of entity — subject to clarifications in the notice's additional eligibility information.

How much funding is available through “NIOSH Centers of Excellence for Total Worker Health® (U19)”?

Per the notice, individual awards are listed as $500k – $1.4m, total estimated program funding is $58,500,000 and the agency expects to make about 10 awards.

How do I apply for “NIOSH Centers of Excellence for Total Worker Health® (U19)”?

Applications are submitted through the official source, not through GrantsJunction. Open the official notice on Grants.gov (opportunity RFA-OH-27-049), and review the full announcement and application package. Organizations applying through Grants.gov generally need an active SAM.gov registration and a Grants.gov account, which can take several weeks to set up.

Matched on shared Assistance Listings, agency, categories and eligible applicant types.