OpenResearch announcementOpportunity RFA-RM-27-007

Cellular Senescence Network (SenNet): SenNet Technology Projects (SenTecs) (UG3/UH3 Clinical Trial Not Allowed)

National Institutes of Health · Department of Health and Human Services

At a glance

Cellular Senescence Network (SenNet): SenNet Technology Projects (SenTecs) (UG3/UH3 Clinical Trial Not Allowed) is an open federal cooperative agreement opportunity from the National Institutes of Health (Department of Health and Human Services). Applications are due November 23, 2026. Total estimated funding is $6M across about 15 awards. Applicant types listed as eligible include state governments, county governments, city or township governments, special district governments, independent school districts and 10 more. Cost sharing is not required. It is funded under Assistance Listing 93.310 (Trans-NIH Research Support).

Summary assembled from the official notice's fields. The official notice governs.

Key facts

Oct 9, 2026Postednext date
Nov 23, 2026Application deadline
Jul 1, 2026 (est.)Est. award date
Jan 22, 2027Archived

Posted: Oct 9, 2026
Close date: Nov 23, 2026
Archive date: Jan 22, 2027
Est. award date: Jul 1, 2026
Award floor: Not specified
Award ceiling: Not specified
Est. total funding: $6,000,000
Implied average award: $400,000 calculated
Expected awards: 15
Cost sharing: Not required
Funding instrument: Cooperative Agreement
Opportunity category: Discretionary

Typical awards for this program (SAM.gov listing for ALN 93.310, not this notice): $3,000 to $27,999,994 with the average being $640,952.

Implied average = estimated total funding ÷ expected number of awards, calculated by GrantsJunction. Actual awards vary.

Who can apply

State governments
County governments
City or township governments
Special district governments
Independent school districts
Public colleges & universities
Federally recognized tribal governments
Public & Indian housing authorities
Native American tribal organizations
501(c)(3) nonprofits
Nonprofits without 501(c)(3) status
Private colleges & universities
For-profit organizations (not small businesses)
Small businesses
Others (see notice)

Additional information on eligibility (from the notice)

Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;Non-domestic (non-U.S.) Entities (Foreign Institutions).

Can your organization apply?

A quick check against the listed applicant types — other requirements in the notice still apply.

Based on the published notice. Review the official notice for complete eligibility requirements.

What it funds

Official synopsis as published by the agency, formatted for readability.

The purpose of this Notice of Funding Opportunity (NOFO) is to solicit the development of innovative senescence technologies (SenTecs), or the adaptation of existing technologies focused on identification, characterization and understanding the biological consequences of senescent cell (SnC) heterogeneity in the context of the tissue environments and secretomes to facilitate novel strategies for modulating SnCs in vivo and for predicting the outcomes of targeting SnCs in human aging and in disease conditions. These are five-year, milestone-driven awards consisting of two phases. The first two years constitute the UG3 phase and are focused on SenTec development and demonstration of technology feasibility. The following 3-years is the SenTec application UH3 phase where SenTecs continue to be optimized, refined and validated. In the final year of the UH3 award, SenTecs will undertake a demonstration project conducted in a collaborative effort within SenNet to provide further validation of the proposed SenTec. Applicants are required to submit both UG3 and UH3 projects together when responding to this NOFO. Transition from the UG3 to UH3 phases is not automatic and will occur only after administrative review of each SenTec at the close of Year 2 of the award.

Full announcement & documents

The full announcement has the complete rules — page limits, required attachments, evaluation criteria and any letter-of-intent dates. Files download directly from Grants.gov.

RFA-RM-27-007-Full-Announcement.htmlFull Announcement · RFA-RM-27-007-Full-Announcement.htmlHTML · 164 KB

How to apply

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Read the full announcement (NOFO)Eligibility, evaluation criteria, page limits and required attachments are in the full notice on Grants.gov. Open ↗
Confirm eligibility and fitCheck your organization type above; no cost sharing is required.
Register (or renew) in SAM.gov and get a UEIFree. New registrations can take several weeks; registrations must be renewed every year. Open ↗
Set up Grants.gov accessCreate a Grants.gov account and make sure someone has the Authorized Organization Representative (AOR) role. Open ↗
Open the application packageUse opportunity number RFA-RM-27-007 on Grants.gov (Grants.gov Workspace). Open ↗
Prepare narrative, budget and attachmentsFollow the notice's format exactly — page limits and required forms are common reasons applications are rejected.
Ask the agency contact any questions earlyNational Institutes of Health · CS2@nih.gov Open ↗
Submit before November 23, 2026Submit a few days early and keep your Grants.gov confirmation and validation emails.

Assistance Listing

What is an ALN?

93.310Trans-NIH Research SupportProgram →

Reported obligations under ALN 93.310

Historical data · not a prediction

FY24

$1.17B

FY25

$1.06B

FY26

$28.1M est.

Source: SAM.gov Assistance Listing 93.310. Program-wide totals, not awards from this specific opportunity.

Who was funded under ALN 93.310

Historical data · not a prediction

Since October 1, 2023, 5,175 grant awards had funding actions under Trans-NIH Research Support, with 7,955 sub-awards passed on to other organizations. These are program-wide awards, not awards from this specific notice.

WASHINGTON UNIVERSITY, THE$96.5M
THE CHILDREN'S HOSPITAL OF PHILADELPHIA$95.5M
THE LELAND STANFORD JUNIOR UNIVERSITY$95.3M
YALE UNIV$81.2M
THE JOHNS HOPKINS UNIVERSITY$76M

Recipients, states, recent awards and sub-awards →Source: USAspending.gov.

Agency contact (as published)

National Institutes of Health
CS2@nih.gov
301-402-2541

Changes we detected

Oct 9, 2026: Contact email changed from ajay.pillai3@nih.gov to CS2@nih.gov
Oct 9, 2026: Title changed
Oct 9, 2026: Close date changed

Quick answers

When is the deadline for this opportunity?

According to the official notice, applications are due November 23, 2026. Confirm the deadline and submission time on Grants.gov before applying.

Who is eligible to apply for this opportunity?

The official notice names these applicant types as eligible: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public colleges & universities, Federally recognized tribal governments, Public & Indian housing authorities, Native American tribal organizations, 501(c)(3) nonprofits, Nonprofits without 501(c)(3) status, Private colleges & universities and 3 more. Additional restrictions may apply; review the full notice.

How much funding is available through this opportunity?

Per the notice, total estimated program funding is $6,000,000 and the agency expects to make about 15 awards.

How do I apply for this opportunity?

Applications are submitted through the official source, not through GrantsJunction. Open the official notice on Grants.gov (opportunity RFA-RM-27-007), and review the full announcement and application package. Organizations applying through Grants.gov generally need an active SAM.gov registration and a Grants.gov account, which can take several weeks to set up.

Matched on shared Assistance Listings, agency, categories and eligible applicant types.

ForecastedResearchALN 93.310