Model-to-Clinic (M2C) for Precision Medicine with AI: Integrating Imaging with Multimodal Data (PRIMED-AI) (UG3/UH3, Clinical Trial Optional)
National Institutes of Health · Department of Health and Human Services
At a glance
Model-to-Clinic (M2C) for Precision Medicine with AI: Integrating Imaging with Multimodal Data (PRIMED-AI) (UG3/UH3, Clinical Trial Optional) is an open federal cooperative agreement opportunity from the National Institutes of Health (Department of Health and Human Services). Applications are due October 19, 2026. Applicant types listed as eligible include state governments, county governments, city or township governments, special district governments, independent school districts and 10 more. Cost sharing is not required. It is funded under Assistance Listing 93.310 (Trans-NIH Research Support).
Summary assembled from the official notice's fields. The official notice governs.
Key facts
- Jun 30, 2026Posted
- Oct 19, 2026Application deadlinenext date
- Mar 1, 2027 (est.)Est. award date
- Dec 18, 2026Archived
- Posted
- Jun 30, 2026
- Close date
- Oct 19, 2026
- Archive date
- Dec 18, 2026
- Est. award date
- Mar 1, 2027
- Award floor
- Not specified
- Award ceiling
- Not specified
- Est. total funding
- Not specified
- Expected awards
- 8
- Cost sharing
- Not required
- Funding instrument
- Cooperative Agreement
- Opportunity category
- Discretionary
Typical awards for this program (SAM.gov listing for ALN 93.310, not this notice): $3,000 to $27,999,994 with the average being $640,952.
Who can apply
- State governments
- County governments
- City or township governments
- Special district governments
- Independent school districts
- Public colleges & universities
- Federally recognized tribal governments
- Public & Indian housing authorities
- Native American tribal organizations
- 501(c)(3) nonprofits
- Nonprofits without 501(c)(3) status
- Private colleges & universities
- For-profit organizations (not small businesses)
- Small businesses
- Others (see notice)
Additional information on eligibility (from the notice)
Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International Collaborations:Non-domestic (non-U.S.) Entities (Foreign Organizations) are eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.
A quick check against the listed applicant types — other requirements in the notice still apply.
Based on the published notice. Review the official notice for complete eligibility requirements.
What it funds
Official synopsis as published by the agency, formatted for readability.
The overarching goal of this notice of funding opportunity (NOFO) and its companion opportunities is to establish the Precision Medicine with AI: Integrating Imaging with Multimodal Data (PRIMED-AI) Program to support development of innovative, reliable, cost-effective, and sustainable multimodal AI-based clinical decision support (CDS) tools. PRIMED-AI CDS tools are based on the integration of clinical imaging with other types of multimodal health data to enhance care for patients with a wide range of health conditions. The PRIMED-AI Program seeks to catalyze the adoption of AI-based CDS tools into clinical workflows to enable novel personalized medicine strategies that address significant health challenges.The purpose of this NOFO is to catalyze the translation of Artificial Intelligence (AI)-enabled, image-centered, multimodal CDS tools, developed as Software as a Medical Device, from training and testing of prototypes towards clinical applications that address unmet health challenges in precision medicine. These projects are expected to have high potential for demonstrable, positive impact on patient outcomes and/or healthcare processes.
Full announcement & documents
The full announcement has the complete rules — page limits, required attachments, evaluation criteria and any letter-of-intent dates. Files download directly from Grants.gov.
How to apply
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Assistance Listing
What is an ALN?Reported obligations under ALN 93.310
Historical data · not a predictionAgency contact (as published)
National Institutes of Health
ODPRIMED-AI@od.nih.gov
301-402-2541
Quick answers
When is the deadline for this opportunity?
According to the official notice, applications are due October 19, 2026. Confirm the deadline and submission time on Grants.gov before applying.
Who is eligible to apply for this opportunity?
The official notice lists these applicant types as eligible: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public colleges & universities, Federally recognized tribal governments, Public & Indian housing authorities, Native American tribal organizations, 501(c)(3) nonprofits, Nonprofits without 501(c)(3) status, Private colleges & universities and 3 more. Additional restrictions may apply; review the full notice.
How do I apply for this opportunity?
Applications are submitted through the official source, not through GrantsJunction. Open the official notice on Grants.gov (opportunity RFA-RM-27-013), and review the full announcement and application package. Organizations applying through Grants.gov generally need an active SAM.gov registration and a Grants.gov account, which can take several weeks to set up.
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