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Assistance Listing 81.049

Office of Science Financial Assistance Program

Department of Energy - Office of Science

Assistance Listing 81.049, “Office of Science Financial Assistance Program,” is a federal program administered by Department of Energy - Office of Science. It provides grant assistance. GrantsJunction currently tracks 4 open, 0 forecasted and 8 closed opportunities under this listing. The agency reported $1.43B in obligations for fiscal year 2025.

Program objective

SC is the Nation’s largest Federal sponsor of basic research in the physical sciences and the lead Federal agency supporting fundamental scientific research for our Nation’s energy future. SC is an established leader of the U.S. scientific discovery and innovation enterprise. Over the decades, SC investments and accomplishments in basic research and enabling research capabilities have provided the foundations for new technologies, businesses, and industries, making significant contributions to our nation’s economy, national security, and quality of life. Additional descriptions of recent science discoveries can be found at https://science.osti.gov/Science-Features/Science-Highlights. SC accomplishes its mission and advances national goals by supporting: - Science for energy, economic and national security―building a foundation of scientific and technical knowledge to spur discoveries and innovations for advancing the Department’s mission. SC supports a wide range of funding modalities from single principal investigators to large team-based activities to engage in fundamental research on energy production, conversion, storage, transmission, and use, and on our understanding of the earth systems. - The frontiers of science—exploring nature’s mysteries from the study of fundamental subatomic particles, atoms, and molecules that are the building blocks of the materials of our universe and everything in it to the DNA, proteins, and cells that are the building blocks of life. Each of the programs in SC supports research probing the most fundamental disciplinary questions. - The 21st Century tools of science—providing the nation’s researchers with 28 state-of-the-art national scientific user facilities, the most advanced tools of modern science, propelling the U.S. to the forefront of science, technology development, and deployment through innovation.

As published in the SAM.gov Assistance Listing.

Current opportunities under 81.049

Closes in 11 daysALN 81.049
Award range
$250K – $200M
Closes
Oct 19, 2026
Who can apply
For-profit organizations (not small businesses) and Small businesses
Source: Grants.govVerified today
OpenALN 81.049
Award range
$20M
Closes
Jan 12, 2027
Who can apply
Public colleges & universities, Private colleges & universities and Others (see notice)
Source: Grants.govVerified today

Eligible applicants (program level)

  • Unrestricted by Entity Type

Except where a program solicitation establishes more restrictive eligibility criteria, individuals and organizations in the following categories may submit proposals: Institutions of higher education; National Laboratories; Nonprofit and for-profit private entities; State and local governments; and consortia of entities described above.

Intended beneficiaries: Quasi-public nonprofit organization, Federally Recognized Indian Tribal Governments, Other public institution/organization, Public nonprofit institution/organization, Local, State, Engineer/Architect, Scientist/Researchers, Graduate Student, Student/Trainee and 7 more.

Program-level eligibility from SAM.gov. Each funding notice sets its own requirements.

Reported obligations by fiscal year

Historical data · not a prediction
FY24$1.7B
FY25$1.43B
FY26$1.5B est.

Range and average of financial assistance (from the listing): $10,000 to $2,500,000; $250,000.

Source: SAM.gov Assistance Listing 81.049. Hatched bars are agency estimates. These totals do not indicate approval rates.

Recently closed under 81.049

Closed opportunities under 81.049
OpportunityStatusAward rangeClosesALN
Closed$50K – $5MSep 30, 202681.049
Closed$100K – $1MMar 3, 202581.049
Closed$250K – $1MJun 14, 202181.049
Closed$20K – $300KFeb 24, 202181.049
Closed$10K – $2MMay 15, 202081.049
Closed$25K – $250KOct 5, 201247.041, 47.049, 47.050, 81.049
ClosedAmount not specifiedJun 25, 201047.049, 47.050, 47.070, 47.074, 47.075, 47.078, 47.080, 81.049
Closed$1M – $1.5MJun 22, 201047.041, 81.049

Frequently asked questions

What is ALN 81.049?

81.049 is the Assistance Listing Number for “Office of Science Financial Assistance Program.” Assistance Listing Numbers (formerly CFDA numbers) identify federal assistance programs; individual grant opportunities reference the listing they are funded under.

Who can apply under ALN 81.049?

The SAM.gov listing names these applicant types: Unrestricted by Entity Type. Each funding notice under the program sets its own eligibility, so check the specific opportunity.

How much funding does 81.049 provide?

The agency reported $1,433,973,496 in obligations for FY2025 in the SAM.gov Assistance Listing. These are program-wide totals reported by the agency, not a prediction of future awards.