Grantmaking public charity · EIN 52-2396428
Alzheimer's Disease Research Foundation
Wellesley Hills, MA
Alzheimer's Disease Research Foundation is a public charity that makes grants based in Wellesley Hills, MA. On its Form 990 (Schedule I) for tax year 2025, it reported $33.8M in grants paid across 161 grants, with $43.2M in total assets. Its largest grants went to Massachusetts General Hospital, Brigham and Women's Hospital and Brigham and Women's Hospital.
How to request funding
Its Form 990 lists the grants it made but not how it chooses recipients. Check Alzheimer's Disease Research Foundation's website or contact it to ask whether it considers requests.
How it makes and monitors grants (Schedule I, Part IV)
The research leadership group reviews each project for fit with the curealz research portfolio, scientific integrity, and value to the search for a cure for alzheimer's disease. all funded researchers may be asked to review occasional proposals on a two-week timeline as a condition of receiving funding. the research committee of the board of directors provides a final review to ensure all procedures have been followed and that the project serves the organization's mission to fund research accelerating benefits to current and potential alzheimer's patients. at least two scientific reviewers must submit a positive review for a proposal to be accepted. any questions or concerns about the proposal by any reviewer may result in a request for iteration or rejection of the proposal. researchers will be advised of acceptance, questions, or rejection but will not receive any "score or assessment commentary from reviewers; however, suggestions or ideas from reviewers are synthesized and provided without attribution if a proposal is funded.
Grants as reported on its Form 990 for tax year 2025; the application guidance above is general for this type of funder. Requirements change; confirm with the organization before applying.
Mission
To fund research with the highest probability of preventing, slowing or reversing alzheimer's disease.
As stated on its Form 990.
Largest grants, tax year 2025
Historical data · not a prediction| Recipient | Location | Purpose | Amount |
|---|---|---|---|
| Massachusetts General Hospital | Boston, MA | The Curealz Alzheimer's Genome Project | $1,955,000 |
| Brigham and Women's Hospital | Boston, MA | Apoe4 Accelerates Cd8 Exhaustion Via Glucocorticoid Signaling in Alzheimer's Female Carriers | $575,000 |
| Brigham and Women's Hospital | Boston, MA | A New Model of Microglia Genetic Perturbation in Vivo to Screen All Risk Factors Associated with Alzheimer's Disease | $431,250 |
| University of Michigan | Ann Arbor, MI | Non-Invasive Modulation of Microglia Gene Expression Using Peripherally Administered Antibody Conjugates | $402,500 |
| Weill Medical College of Cornell University | New York, NY | Sex-Biased Tlr7 Signaling in Demyelination and Its Inhibition by Small Molecules | $402,500 |
| University of California Irvine | Irvine, CA | Proteomic Signatures of Cerebrovascular Neuropathology in Down Syndrome with Alzheimer Disease | $402,492 |
| University of Michigan | Ann Arbor, MI | Utilizing Heterogeneous Mouse Models to Discover Mechanisms Underlying Caloric Restriction (cr) on Cognitive Outcomes | $398,521 |
| Washington University in St Louis | St Louis, MO | Apoe Consortium: Investigating Potential Cell Autonomous Neuroprotection of Apoe Protective Variants | $345,000 |
| Washington University in St Louis | St Louis, MO | Bac: Identifying Age-Related Proteomic Changes That Predict Future Onset of Amyloid-Beta Aggregation in Alzheimer's Disease | $345,000 |
| Washington University in St Louis | St Louis, MO | Bee: Meningeal Mast Cell Control of Csf Dynamics in Homeostasis and Alzheimer's Disease | $345,000 |
| Boston Children's Hospital | Boston, MA | Nic: Effects of Peripheral Inflammation on Myeloid Cell Function in Alzheimer's Disease | $344,528 |
| The Mclean Hospital Corporation | Belmont, MA | Expanding Postmortem Brain Resources for Alzheimer's Disease in Diverse Populations | $327,501 |
| Duke University School of Medicine | Durham, NC | Utility of Blood Based Markers for Predicting Aria and Its Course in Mci and Ad Subjects Undergoing Routine Clinical Treatment with Amyloid-Directed Antibodies | $320,033 |
| Massachusetts General Hospital | Boston, MA | Understanding Human Brain Resilience to Alzheimer's Pathology | $300,000 |
| National Institute of Neurological Disorders & Stroke | Bethesda, MD | Bee: High-Resolution Mri of the Brain Borders | $287,673 |
| Massachusetts General Hospital | Boston, MA | Bee: Human 3d Neuro-Vascular Interaction and Meningeal Lymphatics Models with Application to Alzheimer's Disease | $287,500 |
| New York University School of Medicine | New York, NY | Nic: Astrocyte Inflammatory Contributions to Ad | $287,500 |
| Regents of the University of California San Diego | La Jolla, CA | Bee: How Does Vascular Fatty Acid Metabolism Regulate the Pathophysiology of Alzheimer's Disease? | $287,500 |
| Regents of the University of California San Diego | La Jolla, CA | Nic: Mechanisms Mediating Microglia Sensing of Peripheral Inflammation | $287,500 |
| Stanford University | Redwood City, CA | Bac: Choroid Plexus Aging and Alzheimer's Disease | $287,500 |
| University of Rochester | Rochester, NY | Bee: Does Slym Failure Compromise Glymphatic Clearance in Alzheimer's Disease? | $287,500 |
| Washington University in St Louis | St Louis, MO | Bac: Brain Region and Cell-Type Specific Aging From Accelerated to Resilient Trajectories | $287,500 |
| Washington University in St Louis | St Louis, MO | Bac: Establishing Isogenic Models of Human Neuron Aging and Pathways Relevant for Alzheimer's Disease | $287,499 |
| University of California Irvine | Irvine, CA | Nic: Examining the Impact of Peripherally Derived Human Macrophages in Ad Pathogenesis | $287,490 |
| Massachusetts Institute of Technology | Cambridge, MA | Bac: Investigating Lipidomic Perturbations in the Csf with Age and Alzheimer's Disease Progression: Toward Mechanistic Insights and Accessible Lipid Biomarkers | $287,477 |
The 25 largest of 161 grants listed on the return. Names and purposes as reported to the IRS.
Where its grants went
- Massachusetts$10.4M · 43 grants
- California$5.58M · 26 grants
- New York$4.66M · 24 grants
- Missouri$4.18M · 20 grants
- Texas$1.41M · 8 grants
- Florida$1.24M · 6 grants
- Maryland$1.14M · 7 grants
- Michigan$1.11M · 4 grants
- Virginia$913K · 5 grants
- Pennsylvania$587K · 3 grants
- North Carolina$525K · 2 grants
- Illinois$460K · 3 grants
Quick answers
Does Alzheimer's Disease Research Foundation accept grant applications?
Its Form 990 lists the grants it made but not how it chooses recipients. Check Alzheimer's Disease Research Foundation's website or contact it to ask whether it considers requests. Form 990 does not report an application process, so confirm with the organization.
How much does Alzheimer's Disease Research Foundation give each year?
For tax year 2025, it reported $33,812,354 in grants paid (161 grants). Giving can change from year to year.
What organizations has Alzheimer's Disease Research Foundation funded?
Its largest grants in tax year 2025 went to Massachusetts General Hospital (MA), $1.96M, Brigham and Women's Hospital (MA), $575K, Brigham and Women's Hospital (MA), $431K, University of Michigan (MI), $403K and Weill Medical College of Cornell University (NY), $403K.