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ClosedDeadline moved (was Jan 7, 2027)Research announcementOpportunity PAR-25-355

Multidisciplinary Studies of HIV/AIDS and Aging (R21 Clinical Trial Optional)

National Institutes of Health · Department of Health and Human Services

At a glance

Multidisciplinary Studies of HIV/AIDS and Aging (R21 Clinical Trial Optional) is a closed federal grant opportunity from the National Institutes of Health (Department of Health and Human Services). The application deadline was January 8, 2026. Applicant types listed as eligible include state governments, county governments, city or township governments, special district governments, independent school districts and 10 more. Cost sharing is not required. It is funded under Assistance Listing 93.121 (Oral Diseases and Disorders Research) and 15 other listings.

Summary assembled from the official notice's fields. The official notice governs.

Key facts

  1. Jan 8, 2025Posted
  2. Jan 8, 2026Application deadline
  3. Feb 12, 2027Archivednext date
Posted
Jan 8, 2025
Close date
Jan 8, 2026
Archive date
Feb 12, 2027
Award floor
Not specified
Award ceiling
Not specified
Est. total funding
Not specified
Original deadline
Jan 7, 2027
Expected awards
Not specified
Cost sharing
Not required
Funding instrument
Grant
Opportunity category
Discretionary

Typical awards for this program (SAM.gov listing for ALN 93.121, not this notice): FY2023: research project grants: range $10,355-$3,198,621, average $493,453; NRSA: range $12,200-$645,669, average $102,286; SBIR/STTR: range $44,553-$1,265,448, average $734,953; Career development: range $19,566-$283,536, average $151,550. FY2024: research project grants: range $14,491-$3,134,285, average $499,286; NRSA: range $2,500-$689,065, average $117,487; SBIR/STTR: range $44,553-$1,493,635, average $721,489; Career development: range $12,905-$282,170, average $156,332.

Who can apply

  • State governments
  • County governments
  • City or township governments
  • Special district governments
  • Independent school districts
  • Public colleges & universities
  • Federally recognized tribal governments
  • Public & Indian housing authorities
  • Native American tribal organizations
  • 501(c)(3) nonprofits
  • Nonprofits without 501(c)(3) status
  • Private colleges & universities
  • For-profit organizations (not small businesses)
  • Small businesses
  • Others (see notice)

Additional information on eligibility (from the notice)

Other Eligible Applicants include the following: Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; Tribally Controlled Colleges and Universities (TCCUs) ; U.S. Territory or Possession.

A quick check against the listed applicant types — other requirements in the notice still apply.

Based on the published notice. Review the official notice for complete eligibility requirements.

What it funds

Official synopsis as published by the agency, formatted for readability.

This NOFO invites applications at the intersection of HIV and aging by proposing research that aims to meet the following objectives:1) Improve the understanding of biological, clinical, and socio-behavioral aspects of aging through the lens of HIV infection and its treatment; and2) Improve approaches for testing, preventing, and treating HIV infection, and managing HIV-related comorbidities, co-infections, and complications in different populations and cultural settings by applying current aging science approaches.Proposed research must be consistent with the HIV/AIDS Research Priorities outlined by NIHs Office of AIDS Research (OAR), as described inNOT-OD-20-018.

Additional information from the agency ↗

Full announcement & documents

The full announcement has the complete rules — page limits, required attachments, evaluation criteria and any letter-of-intent dates. Files download directly from Grants.gov.

Assistance Listings

What is an ALN?

Reported obligations under ALN 93.121

Historical data · not a prediction
FY24$320M
FY25$332M
FY26$337M est.
Source: SAM.gov Assistance Listing 93.121. Program-wide totals, not awards from this specific opportunity.

Agency contact (as published)

National Institutes of Health
grantsinfo@nih.gov
301-402-2541

Quick answers

Who is eligible to apply for “Multidisciplinary Studies of HIV/AIDS and Aging (R21 Clinical Trial Optional)”?

The official notice lists these applicant types as eligible: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public colleges & universities, Federally recognized tribal governments, Public & Indian housing authorities, Native American tribal organizations, 501(c)(3) nonprofits, Nonprofits without 501(c)(3) status, Private colleges & universities and 3 more. Additional restrictions may apply; review the full notice.

How do I apply for “Multidisciplinary Studies of HIV/AIDS and Aging (R21 Clinical Trial Optional)”?

Applications are submitted through the official source, not through GrantsJunction. Open the official notice on Grants.gov (opportunity PAR-25-355), and review the full announcement and application package. Organizations applying through Grants.gov generally need an active SAM.gov registration and a Grants.gov account, which can take several weeks to set up.

Matched on shared Assistance Listings, agency, categories and eligible applicant types.