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ClosedOpportunity RFA-CA-27-012

Metastasis Research Network (U54 Clinical Trial Not Allowed)

National Institutes of Health · Department of Health and Human Services

At a glance

Metastasis Research Network (U54 Clinical Trial Not Allowed) is a closed federal cooperative agreement opportunity from the National Institutes of Health (Department of Health and Human Services). The application deadline was September 25, 2026. Individual awards are listed as up to $1.3M, with about 4 awards expected and $6.8M in total estimated funding. Applicant types listed as eligible include state governments, county governments, city or township governments, special district governments, independent school districts and 10 more. Cost sharing is not required. It is funded under Assistance Listing 93.396 (Cancer Biology Research).

Summary assembled from the official notice's fields. The official notice governs.

Key facts

Posted
Jun 4, 2026
Close date
Sep 25, 2026
Archive date
Nov 24, 2026
Est. award date
Mar 1, 2027
Award floor
Not specified
Award ceiling
$1,300,000
Est. total funding
$6,800,000
Expected awards
4
Cost sharing
Not required
Funding instrument
Cooperative Agreement
Opportunity category
Discretionary

Who can apply

  • State governments
  • County governments
  • City or township governments
  • Special district governments
  • Independent school districts
  • Public colleges & universities
  • Federally recognized tribal governments
  • Public & Indian housing authorities
  • Native American tribal organizations
  • 501(c)(3) nonprofits
  • Nonprofits without 501(c)(3) status
  • Private colleges & universities
  • For-profit organizations (not small businesses)
  • Small businesses
  • Others (see notice)

Additional information on eligibility (from the notice)

Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International Collaborations:Non-domestic (non-U.S.) Entities (Foreign Organizations) are eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

Based on the published notice. Review the official notice for complete eligibility requirements.

What it funds

Official synopsis as published by the agency, formatted for readability.

Through this Notice of Funding Opportunity (NOFO), the National Cancer Institute (NCI) solicits applications for research on developing a comprehensive and cohesive understanding of cancer metastasis. Towards this goal, the NCI will support U54 Specialized Centers that together will continue to serve as the hub of the Metastasis Research Network (MetNet). Each MetNet Center should propose an overarching scientific theme that will be pursued through two or three scientific inter- and multidisciplinary basic research projects. The projects should use integrative system level approaches to elucidate and integrate a mechanistic understanding of the non-linear, dynamic, and emergent processes in metastasis. Overarching themes should encompass the interplay between at least two central elements in the metastatic process such as early dissemination, cellular, soluble and/or physical microenvironment crosstalk, dormancy, or mechanisms of responses by metastatic cells to therapies. Studies on all types of cancer are welcome, including rare and pediatric metastatic cancers.Research proposed by MetNet Centers is expected to advance our understanding towards a more comprehensive appreciation of metastasis as a whole body, systems-level problem.

Assistance Listing

What is an ALN?

Reported obligations under ALN 93.396

Historical data · not a prediction
FY24$893M
FY25$936M
FY26$580M est.
Source: SAM.gov Assistance Listing 93.396. Program-wide totals, not awards from this specific opportunity.

Agency contact (as published)

National Institutes of Health
NCIMetNet@mail.nih.gov
301-402-2541

Quick answers

Who is eligible to apply for “Metastasis Research Network (U54 Clinical Trial Not Allowed)”?

The official notice lists these applicant types as eligible: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public colleges & universities, Federally recognized tribal governments, Public & Indian housing authorities, Native American tribal organizations, 501(c)(3) nonprofits, Nonprofits without 501(c)(3) status, Private colleges & universities and 3 more. Additional restrictions may apply; review the full notice.

How much funding is available through “Metastasis Research Network (U54 Clinical Trial Not Allowed)”?

Per the notice, individual awards are listed as up to $1.3m, total estimated program funding is $6,800,000 and the agency expects to make about 4 awards.

How do I apply for “Metastasis Research Network (U54 Clinical Trial Not Allowed)”?

Applications are submitted through the official source, not through GrantsJunction. Open the official notice on Grants.gov (opportunity RFA-CA-27-012), and review the full announcement and application package. Organizations applying through Grants.gov generally need an active SAM.gov registration and a Grants.gov account, which can take several weeks to set up.

Matched on shared Assistance Listings, agency, categories and eligible applicant types.