ForecastedResearch announcementOpportunity PAR-26-105

ORACLE 3C: Chronic Conditions, Coinfections, and Comorbidities in HIV

National Institutes of Health · Department of Health and Human Services

At a glance

ORACLE 3C: Chronic Conditions, Coinfections, and Comorbidities in HIV is a forecasted federal grant opportunity from the National Institutes of Health (Department of Health and Human Services). The agency's forecast estimates an application due date of September 25, 2026; forecast dates can change. Total estimated funding is $1.96M across about 4 awards. Applicant types listed as eligible include state governments, county governments, city or township governments, special district governments, independent school districts and 10 more. Cost sharing is not required. It is funded under Assistance Listing 93.865 (Child Health and Human Development Extramural Research).

Summary assembled from the official notice's fields. The official notice governs.

Key facts

Feb 6, 2026Forecast posted
Jul 24, 2026 (est.)Full notice expected
Sep 25, 2026 (est.)Application deadline
Jul 22, 2027 (est.)Est. award datenext date

Posted: Feb 6, 2026
Est. close date: Sep 25, 2026
Est. award date: Jul 22, 2027
Award floor: Not specified
Award ceiling: Not specified
Est. total funding: $1,960,000
Implied average award: $490,000 calculated
Expected awards: 4
Cost sharing: Not required
Funding instrument: Grant
Opportunity category: Discretionary
Fiscal year: FY2027

Typical awards for this program (SAM.gov listing for ALN 93.865, not this notice): For research project grants, fiscal year 2024, range is $50,000 to $5,000,000; average is $534,606. Individual research fellowship awards: Basic stipend (first year beyond the doctoral degree) of approximately $45,000. The sponsoring institution will be provided, on application, with an allowance of up to approximately $8,000 per year to help defray the cost of training. No dependency allowances. SBIR: Average Phase I awards are for approximately $225,000 (grant activity R43 - for up to six months); Phase II awards may be made for amounts up to $1,500,000 (grant activity R44 - for up to two years).

Implied average = estimated total funding ÷ expected number of awards, calculated by GrantsJunction. Actual awards vary.

Who can apply

State governments
County governments
City or township governments
Special district governments
Independent school districts
Public colleges & universities
Federally recognized tribal governments
Public & Indian housing authorities
Native American tribal organizations
501(c)(3) nonprofits
Nonprofits without 501(c)(3) status
Private colleges & universities
For-profit organizations (not small businesses)
Small businesses
Others (see notice)

Additional information on eligibility (from the notice)

Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;Non-domestic (non-U.S.) Entities (Foreign Institutions).

Can your organization apply?

A quick check against the listed applicant types — other requirements in the notice still apply.

Based on the published notice. Review the official notice for complete eligibility requirements.

What it funds

Official synopsis as published by the agency, formatted for readability.

NICHD will advance its mission by using the DP2 mechanism to support early-career investigators conducting pioneering research on HIV-related chronic conditions, coinfections, and comorbidities (3C). Scientific directions will be distinct from concepts and approaches already pursued and consistent with the scientific priorities of the Office of AIDS Research (OAR). HIV-related 3Cs cause significant and different pathology in people with and without HIV. Development of preventive and therapeutic strategies based on understanding HIV-specific pathways and mechanisms, and implementing those strategies is critical, especially in pediatric and maternal populations. All pediatric and maternal populations will be appropriate for study as the focus is on HIV prevention and/or treatment research. A pipeline of innovative researchers from other fields of research including mathematics, engineering, computer science, and AI will bring new ideas and innovative approaches. This NOFO will advance research on an important public health problem by supporting transformative research on HIV 3Cs by investigators in the early stages of an independent career.

How to apply

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Read the full announcement (NOFO)Eligibility, evaluation criteria, page limits and required attachments are in the full notice on Grants.gov. Open ↗
Confirm eligibility and fitCheck your organization type above; no cost sharing is required.
Register (or renew) in SAM.gov and get a UEIFree. New registrations can take several weeks; registrations must be renewed every year. Open ↗
Set up Grants.gov accessCreate a Grants.gov account and make sure someone has the Authorized Organization Representative (AOR) role. Open ↗
Watch for the full noticeThe agency estimates posting it around July 24, 2026. Save this grant to track changes.
Prepare narrative, budget and attachmentsFollow the notice's format exactly — page limits and required forms are common reasons applications are rejected.
Ask the agency contact any questions earlyNICHD MPIDB · NICHD_MPIDB_Opportunities@mail.nih.gov Open ↗
Submit before September 25, 2026Submit a few days early and keep your Grants.gov confirmation and validation emails.

Assistance Listing

What is an ALN?

93.865Child Health and Human Development Extramural ResearchProgram →

Reported obligations under ALN 93.865

Historical data · not a prediction

FY24

$1.28B

FY25

$1.33B

FY26

$185M est.

Source: SAM.gov Assistance Listing 93.865. Program-wide totals, not awards from this specific opportunity.

Who was funded under ALN 93.865

Historical data · not a prediction

Since October 1, 2023, 6,805 grant awards had funding actions under Child Health and Human Development Extramural Research, with 5,427 sub-awards passed on to other organizations. These are program-wide awards, not awards from this specific notice.

REGENTS OF THE UNIVERSITY OF MICHIGAN$111M
UNIVERSITY OF WASHINGTON$99.9M
THE JOHNS HOPKINS UNIVERSITY$92.1M
REGENTS OF THE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, THE$77M
TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, THE$74.4M

Recipients, states, recent awards and sub-awards →Source: USAspending.gov.

Agency contact (as published)

NICHD MPIDB
NICHD_MPIDB_Opportunities@mail.nih.gov
Please contact via e-mail

Quick answers

Is “ORACLE 3C: Chronic Conditions, Coinfections, and Comorbidities in HIV” open for applications yet?

Not yet. It is a forecast — an agency's advance notice of an expected opportunity. The agency estimates posting the full notice around July 24, 2026. Forecast details and dates can change.

Who is eligible to apply for “ORACLE 3C: Chronic Conditions, Coinfections, and Comorbidities in HIV”?

The official notice names these applicant types as eligible: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public colleges & universities, Federally recognized tribal governments, Public & Indian housing authorities, Native American tribal organizations, 501(c)(3) nonprofits, Nonprofits without 501(c)(3) status, Private colleges & universities and 3 more. Additional restrictions may apply; review the full notice.

How much funding is available through “ORACLE 3C: Chronic Conditions, Coinfections, and Comorbidities in HIV”?

Per the notice, total estimated program funding is $1,960,000 and the agency expects to make about 4 awards.

How do I apply for “ORACLE 3C: Chronic Conditions, Coinfections, and Comorbidities in HIV”?

Applications are submitted through the official source, not through GrantsJunction. Open the official notice on Grants.gov (opportunity PAR-26-105), and review the full announcement and application package. Organizations applying through Grants.gov generally need an active SAM.gov registration and a Grants.gov account, which can take several weeks to set up.

Matched on shared Assistance Listings, agency, categories and eligible applicant types.

ForecastedResearchALN 93.865