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ForecastedResearch announcementOpportunity PAR-27-039

Small Business Transition Grant for New Entrepreneurs (Parent R43/R44 Clinical Trial Optional)

National Institutes of Health · Department of Health and Human Services

At a glance

Small Business Transition Grant for New Entrepreneurs (Parent R43/R44 Clinical Trial Optional) is a forecasted federal grant opportunity from the National Institutes of Health (Department of Health and Human Services). The agency's forecast estimates an application due date of January 5, 2027; forecast dates can change. Applicant types listed as eligible include small businesses. Cost sharing is not required. It is funded under Assistance Listing 93.113 (Environmental Health) and 21 other listings.

Summary assembled from the official notice's fields. The official notice governs.

Key facts

  1. May 27, 2026Forecast posted
  2. Nov 5, 2026 (est.)Full notice expectednext date
  3. Jan 5, 2027 (est.)Application deadline
  4. Jun 1, 2027 (est.)Est. award date
Posted
May 27, 2026
Est. close date
Jan 5, 2027
Est. award date
Jun 1, 2027
Award floor
Not specified
Award ceiling
Not specified
Est. total funding
Not specified
Expected awards
Not specified
Cost sharing
Not required
Funding instrument
Grant
Opportunity category
Discretionary
Fiscal year
FY2027

Typical awards for this program (SAM.gov listing for ALN 93.113, not this notice): Range: $2,500 to $6,747,780 Average: $444,487

Who can apply

  • Small businesses

Additional information on eligibility (from the notice)

Only United States small business concerns (SBCs), as defined by the Small Business Administration (SBA)(sbir.gov/apply) are eligible to submit applications for this opportunity. Individuals are eligible to serve as the PD/PI if they have never been an independent PD/PI on an NIH or CDC research, or corresponding non-NIH peer-reviewed research grant, and are a U.S. Citizen or Lawful Permanent Resident.

A quick check against the listed applicant types — other requirements in the notice still apply.

Based on the published notice. Review the official notice for complete eligibility requirements.

What it funds

Official synopsis as published by the agency, formatted for readability.

The National Institutes of Health (NIH) and Centers for Disease Control and Prevention (CDC), including the participating Institutes, Centers and Offices, intend to publish a Notice of Funding Opportunity (NOFO) to invite eligible United States small business concerns (SBCs) to submit Small Business Innovation Research (SBIR) Phase I, and Fast-Track (NIH only) grant applications for the Small Business Transition Grant. Through this NOFO, NIH and CDC will support early-career scientists as they transition into entrepreneurship. In addition to funding research and development efforts at the SBC, a major component of this NOFO is entrepreneurial training, mentoring, and career development of the PD/PI.

Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop responsive projects, including identification of complementary industry mentors and career development resources. This NOFO will utilize the R43/R44 activity code. United States small businesses that have the research capabilities and technological expertise to contribute to the R&D mission(s) of the NIH and CDC awarding components identified in this NOFO are encouraged to begin to consider applying for this new NOFO. This opportunity is available to first-time Principal Investigators, and key personnel must include a mentor with measurable effort committed to the project. 

How to apply

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Assistance Listings

What is an ALN?

Reported obligations under ALN 93.113

Historical data · not a prediction
FY24$446M
FY25$466M
FY26$40.3M est.
Source: SAM.gov Assistance Listing 93.113. Program-wide totals, not awards from this specific opportunity.

Agency contact (as published)

NIH SEED (Small business Education and Entrepreneurial Development) Office of Extramural Research (OER)
SEEDinfo@nih.gov
301-827-8595

Quick answers

Is this opportunity open for applications yet?

Not yet. It is a forecast — an agency's advance notice of an expected opportunity. The agency estimates posting the full notice around November 5, 2026. Forecast details and dates can change.

Who is eligible to apply for this opportunity?

The official notice lists these applicant types as eligible: Small businesses. Additional restrictions may apply; review the full notice.

How do I apply for this opportunity?

Applications are submitted through the official source, not through GrantsJunction. Open the official notice on Grants.gov (opportunity PAR-27-039), and review the full announcement and application package. Organizations applying through Grants.gov generally need an active SAM.gov registration and a Grants.gov account, which can take several weeks to set up.

Matched on shared Assistance Listings, agency, categories and eligible applicant types.