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OpenResearch announcementOpportunity RFA-AI-27-018

Implementation Science to Advance HIV Prevention, Treatment, and Care (R61/R33 Clinical Trial Optional)

National Institutes of Health · Department of Health and Human Services

At a glance

Implementation Science to Advance HIV Prevention, Treatment, and Care (R61/R33 Clinical Trial Optional) is an open federal grant opportunity from the National Institutes of Health (Department of Health and Human Services). Applications are due June 20, 2029. Total estimated funding is $7M across about 10 awards. Applicant types listed as eligible include state governments, county governments, city or township governments, special district governments, independent school districts and 10 more. Cost sharing is not required. It is funded under Assistance Listing 93.121 (Oral Diseases and Disorders Research) and 21 other listings.

Summary assembled from the official notice's fields. The official notice governs.

Key facts

  1. Oct 6, 2026Posted
  2. Jun 20, 2029Application deadlinenext date
  3. Dec 1, 2026 (est.)Est. award date
  4. Aug 20, 2029Archived
Posted
Oct 6, 2026
Close date
Jun 20, 2029
Archive date
Aug 20, 2029
Est. award date
Dec 1, 2026
Award floor
Not specified
Award ceiling
Not specified
Est. total funding
$7,000,000
Implied average award
$700,000 calculated
Expected awards
10
Cost sharing
Not required
Funding instrument
Grant
Opportunity category
Discretionary

Typical awards for this program (SAM.gov listing for ALN 93.121, not this notice): FY2023: research project grants: range $10,355-$3,198,621, average $493,453; NRSA: range $12,200-$645,669, average $102,286; SBIR/STTR: range $44,553-$1,265,448, average $734,953; Career development: range $19,566-$283,536, average $151,550. FY2024: research project grants: range $14,491-$3,134,285, average $499,286; NRSA: range $2,500-$689,065, average $117,487; SBIR/STTR: range $44,553-$1,493,635, average $721,489; Career development: range $12,905-$282,170, average $156,332.

Implied average = estimated total funding ÷ expected number of awards, calculated by GrantsJunction. Actual awards vary.

Who can apply

  • State governments
  • County governments
  • City or township governments
  • Special district governments
  • Independent school districts
  • Public colleges & universities
  • Federally recognized tribal governments
  • Public & Indian housing authorities
  • Native American tribal organizations
  • 501(c)(3) nonprofits
  • Nonprofits without 501(c)(3) status
  • Private colleges & universities
  • For-profit organizations (not small businesses)
  • Small businesses
  • Others (see notice)

Additional information on eligibility (from the notice)

Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;Non-domestic (non-U.S.) Entities (Foreign Institutions).

A quick check against the listed applicant types — other requirements in the notice still apply.

Based on the published notice. Review the official notice for complete eligibility requirements.

What it funds

Official synopsis as published by the agency, formatted for readability.

The purpose of this notice of funding opportunity (NOFO) is to support implementation research on strategies to improve the uptake, implementation, sustainment, scale and/or spread of evidence-based prevention, treatment, and care interventions in communities in the U.S. significantly impacted by HIV. Projects should be large in scale with high potential for research and public health impact. Specifically, large single site studies, multi-site studies, and comparative studies are encouraged as scientifically appropriate.

Full announcement & documents

The full announcement has the complete rules — page limits, required attachments, evaluation criteria and any letter-of-intent dates. Files download directly from Grants.gov.

How to apply

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Assistance Listings

What is an ALN?

Reported obligations under ALN 93.121

Historical data · not a prediction
FY24$320M
FY25$332M
FY26$337M est.
Source: SAM.gov Assistance Listing 93.121. Program-wide totals, not awards from this specific opportunity.

Agency contact (as published)

National Institutes of Health
OD-OARHIVISRFA27-018@nih.gov
301-402-2541

Quick answers

When is the deadline for this opportunity?

According to the official notice, applications are due June 20, 2029. Confirm the deadline and submission time on Grants.gov before applying.

Who is eligible to apply for this opportunity?

The official notice lists these applicant types as eligible: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public colleges & universities, Federally recognized tribal governments, Public & Indian housing authorities, Native American tribal organizations, 501(c)(3) nonprofits, Nonprofits without 501(c)(3) status, Private colleges & universities and 3 more. Additional restrictions may apply; review the full notice.

How much funding is available through this opportunity?

Per the notice, total estimated program funding is $7,000,000 and the agency expects to make about 10 awards.

How do I apply for this opportunity?

Applications are submitted through the official source, not through GrantsJunction. Open the official notice on Grants.gov (opportunity RFA-AI-27-018), and review the full announcement and application package. Organizations applying through Grants.gov generally need an active SAM.gov registration and a Grants.gov account, which can take several weeks to set up.

Matched on shared Assistance Listings, agency, categories and eligible applicant types.