ForecastedOpportunity RFA-AI-28-008

Clinical Trials in Organ Transplantation in Children and Adults

National Institutes of Health · Department of Health and Human Services

At a glance

Clinical Trials in Organ Transplantation in Children and Adults is a forecasted federal cooperative agreement opportunity from the National Institutes of Health (Department of Health and Human Services). The agency's forecast estimates an application due date of September 30, 2027; forecast dates can change. Total estimated funding is $11.3M across about 4 awards. Applicant types listed as eligible include state governments, county governments, city or township governments, special district governments, independent school districts and 10 more. Cost sharing is not required. It is funded under Assistance Listing 93.855 (Allergy and Infectious Diseases Research).

Summary assembled from the official notice's fields. The official notice governs.

Key facts

Posted: Jun 24, 2026
Est. close date: Sep 30, 2027
Est. award date: Jul 1, 2028
Award floor: Not specified
Award ceiling: Not specified
Est. total funding: $11,280,000
Expected awards: 4
Cost sharing: Not required
Funding instrument: Cooperative Agreement
Opportunity category: Discretionary
Fiscal year: FY2028

Who can apply

State governments
County governments
City or township governments
Special district governments
Independent school districts
Public colleges & universities
Federally recognized tribal governments
Public & Indian housing authorities
Native American tribal organizations
501(c)(3) nonprofits
Nonprofits without 501(c)(3) status
Private colleges & universities
For-profit organizations (not small businesses)
Small businesses
Others (see notice)

Additional information on eligibility (from the notice)

Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;Non-domestic (non-U.S.) Entities (Foreign Institutions).

Based on the published notice. Review the official notice for complete eligibility requirements.

What it funds

Official synopsis as published by the agency, formatted for readability.

The National Institute of Allergy and Infectious Diseases (NIAID) seeks to advance its mission through the continued support of the Clinical Trials in Organ Transplantation in Children and Adults (CTOT-CA) program. The goal of the CTOT-CA is to improve the outcome of organ transplantation through clinical trials with mechanistic studies. The CTOT-CA will support multicenter clinical trials, with associated studies of immune mechanisms, in heart, lung, kidney, liver, and intestinal transplantation. The program will also support clinical trials of non-hematopoietic cellular transplantation as replacement therapies; vascularized composite tissue transplantation; and transplantation of bone marrow or mesenchymal stem cells, or of immunologically active cells, as adjuncts to organ transplantation. Grant authorities that allow NIAID to forecast this opportunity are as follows: Sections 301 and 405 of the Public Health Service Act as amended (42 USC 241 and 284) and under Federal Regulations 42 CFR Part 52 and 2 CFR Part 200.

Assistance Listing

What is an ALN?

93.855Allergy and Infectious Diseases ResearchProgram →

Reported obligations under ALN 93.855

Historical data · not a prediction

FY24

$4.07B

FY25

$4.38B

FY26

$4.3B est.

Source: SAM.gov Assistance Listing 93.855. Program-wide totals, not awards from this specific opportunity.

Agency contact (as published)

DAIT Transplantation Branch Clinical Trial Leadership
CTOT_CA_U01@mail.nih.gov
Please contact via email.

Quick answers

Is “Clinical Trials in Organ Transplantation in Children and Adults” open for applications yet?

Not yet. It is a forecast — an agency's advance notice of an expected opportunity. The agency estimates posting the full notice around June 17, 2027. Forecast details and dates can change.

Who is eligible to apply for “Clinical Trials in Organ Transplantation in Children and Adults”?

The official notice lists these applicant types as eligible: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public colleges & universities, Federally recognized tribal governments, Public & Indian housing authorities, Native American tribal organizations, 501(c)(3) nonprofits, Nonprofits without 501(c)(3) status, Private colleges & universities and 3 more. Additional restrictions may apply; review the full notice.

How much funding is available through “Clinical Trials in Organ Transplantation in Children and Adults”?

Per the notice, total estimated program funding is $11,280,000 and the agency expects to make about 4 awards.

How do I apply for “Clinical Trials in Organ Transplantation in Children and Adults”?

Applications are submitted through the official source, not through GrantsJunction. Open the official notice on Grants.gov (opportunity RFA-AI-28-008), and review the full announcement and application package. Organizations applying through Grants.gov generally need an active SAM.gov registration and a Grants.gov account, which can take several weeks to set up.

Matched on shared Assistance Listings, agency, categories and eligible applicant types.

ForecastedALN 93.855