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ForecastedOpportunity RFA-DA-27-012

NIH Blueprint Initiative: Tools for Germline Gene Editing in the Nervous System

National Institutes of Health · Department of Health and Human Services

At a glance

NIH Blueprint Initiative: Tools for Germline Gene Editing in the Nervous System is a forecasted federal cooperative agreement opportunity from the National Institutes of Health (Department of Health and Human Services). The agency's forecast estimates an application due date of October 12, 2026; forecast dates can change. Individual awards are listed as up to $1.2M, with about 4 awards expected and $7.2M in total estimated funding. Applicant types listed as eligible include state governments, county governments, city or township governments, special district governments, independent school districts and 10 more. Cost sharing is not required. It is funded under Assistance Listing 93.279 (Drug Use and Addiction Research Programs).

Summary assembled from the official notice's fields. The official notice governs.

Key facts

Posted
May 7, 2026
Est. close date
Oct 12, 2026
Est. award date
Jul 1, 2027
Award floor
Not specified
Award ceiling
$1,200,000
Est. total funding
$7,200,000
Expected awards
4
Cost sharing
Not required
Funding instrument
Cooperative Agreement
Opportunity category
Discretionary
Fiscal year
FY2027

Who can apply

  • State governments
  • County governments
  • City or township governments
  • Special district governments
  • Independent school districts
  • Public colleges & universities
  • Federally recognized tribal governments
  • Public & Indian housing authorities
  • Native American tribal organizations
  • 501(c)(3) nonprofits
  • Nonprofits without 501(c)(3) status
  • Private colleges & universities
  • For-profit organizations (not small businesses)
  • Small businesses
  • Others (see notice)

Additional information on eligibility (from the notice)

Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;Non-domestic (non-U.S.) Entities (Foreign Institutions).

Based on the published notice. Review the official notice for complete eligibility requirements.

What it funds

Official synopsis as published by the agency, formatted for readability.

The NIH Blueprint (a consortium of NIH Institutes that support neuroscience research) seeks to advance its mission by supporting the development, optimization, validation, and application of germline and somatic transgenic and gene-editing approaches in experimental systems modeling key features of human brain anatomy, circuitry, cognition, behavior, and lifespan. This initiative will build on the previously supported marmoset gene-editing infrastructure, by integrating New Approach Methodologies (NAMs) with other models, to advance understanding of human brain function and disease, including human-derived NAMs for cross-species comparisons across development. Many mechanisms of complex conditions, such as autism spectrum disorders, schizophrenia, and other behavioral/developmental disorders, cannot yet be captured in NAMs and are therefore high priorities for research investment to accelerate development and validation of human-derived NAMs. Appropriate models should be used and clearly justified as necessary for questions involving neuroanatomy, circuit function, cognition, behavior, or lifespan phenotyping related to human brain disease and function. Grant authorities are as follows: 42 U.S.C 241 and 284.

Assistance Listing

What is an ALN?

Reported obligations under ALN 93.279

Historical data · not a prediction
FY24$1.25B
FY25$1.34B
FY26$20.2M est.
Source: SAM.gov Assistance Listing 93.279. Program-wide totals, not awards from this specific opportunity.

Agency contact (as published)

NIDA GED Program Staff
NIDA_GED_Program@nida.nih.gov
Please contact via e-mail

Quick answers

Is “NIH Blueprint Initiative: Tools for Germline Gene Editing in the Nervous System” open for applications yet?

Not yet. It is a forecast — an agency's advance notice of an expected opportunity. The agency estimates posting the full notice around August 10, 2026. Forecast details and dates can change.

Who is eligible to apply for “NIH Blueprint Initiative: Tools for Germline Gene Editing in the Nervous System”?

The official notice lists these applicant types as eligible: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public colleges & universities, Federally recognized tribal governments, Public & Indian housing authorities, Native American tribal organizations, 501(c)(3) nonprofits, Nonprofits without 501(c)(3) status, Private colleges & universities and 3 more. Additional restrictions may apply; review the full notice.

How much funding is available through “NIH Blueprint Initiative: Tools for Germline Gene Editing in the Nervous System”?

Per the notice, individual awards are listed as up to $1.2m, total estimated program funding is $7,200,000 and the agency expects to make about 4 awards.

How do I apply for “NIH Blueprint Initiative: Tools for Germline Gene Editing in the Nervous System”?

Applications are submitted through the official source, not through GrantsJunction. Open the official notice on Grants.gov (opportunity RFA-DA-27-012), and review the full announcement and application package. Organizations applying through Grants.gov generally need an active SAM.gov registration and a Grants.gov account, which can take several weeks to set up.

Matched on shared Assistance Listings, agency, categories and eligible applicant types.