Closes in 1 dayALN 81.121
- Award range
- Up to $2M
- Closes
- Oct 9, 2026
- Who can apply
- State governments, Public colleges & universities, Federally recognized tribal governments and 6 more
Grants by applicant type
Federal grants for 501(c)(3) organizations
These opportunities list “Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education” as an eligible applicant type in the official notice.
GrantsJunction currently lists 425 open and 436 forecasted federal opportunities for 501(c)(3) organizations. 59 close within the next 30 days, the next on October 9, 2026. The most active agencies are Department of Health and Human Services, Department of Justice and Department of State. The largest listed award ceiling is $120M. 41 require cost sharing.
Counts are calculated from official Grants.gov records as of Oct 8, 2026.
425Open now
436Forecasted
59Closing in 30 days
92Posted in last 30 days
Open and forecasted opportunities
Filter all 861 in search →Closes in 1 dayALN 93.310
Development and Testing of a Multi-use Frameworks Playbook for Precision Medicine with AI: Integrating Imaging with Multimodal Data (PRIMED-AI) (U01 Clinical Trial Not Allowed)
National Institutes of Health- Award range
- Up to $300K
- Closes
- Oct 9, 2026
- Who can apply
- State governments, County governments, City or township governments and 12 more
Closes in 1 dayALN 93.847
Optimal Treatment Strategies for use of Anti-Obesity Medications (AOMs) in Children and Adolescents Clinical Centers (U01 Clinical Trial Required)
National Institutes of Health- Award range
- Up to $1M
- Closes
- Oct 9, 2026
- Who can apply
- State governments, County governments, City or township governments and 12 more
Closes in 1 dayALN 93.847
Optimal Treatment Strategies for use of Anti-Obesity Medications (AOMs) in Children and Adolescents Research Coordinating Center (U24 Clinical Trial Not Allowed)
National Institutes of Health- Award range
- Amount not specified
- Closes
- Oct 9, 2026
- Who can apply
- State governments, County governments, City or township governments and 12 more
ForecastedALN 93.855
Cooperative Program for Modeling Clinical Transplantation
National Institutes of Health- Award range
- Amount not specified
- Est. close
- Oct 9, 2026 (est.)
- Who can apply
- State governments, County governments, City or township governments and 12 more
Closes in 3 daysALN 93.242, 93.279
Addressing Methodological Challenges with Clinical Trials of Rapid-Acting Psychotropic Interventional Drugs (RAPIDs) (R01 Clinical Trial Required)
National Institutes of Health- Award range
- Amount not specified
- Closes
- Oct 11, 2026
- Who can apply
- State governments, County governments, City or township governments and 12 more
Closes in 4 daysALN 10.675
- Award range
- $200K – $750K
- Closes
- Oct 12, 2026
- Who can apply
- State governments, County governments, City or township governments and 6 more
ForecastedALN 93.279
NIH Blueprint Initiative: Tools for Germline Gene Editing in the Nervous System
National Institutes of Health- Award range
- Up to $1.2M
- Est. close
- Oct 12, 2026 (est.)
- Who can apply
- State governments, County governments, City or township governments and 12 more
ForecastedALN 93.853
HEAL Initiative: Program to Reveal and Evaluate Cells-to-gene Information that Specify Intricacies, Origins and the Nature of (PRECISION) Human Pain Network
National Institutes of Health- Award range
- Amount not specified
- Est. close
- Oct 12, 2026 (est.)
- Who can apply
- State governments, County governments, City or township governments and 12 more
Closes in 5 daysALN 10.689
Community Forest and Open Space Conservation Program
Forest Service- Award range
- $1 – $600K
- Closes
- Oct 13, 2026
- Who can apply
- City or township governments, Federally recognized tribal governments and 501(c)(3) nonprofits
Closes in 5 daysALN 15.688
F26AS00062: Great Lakes Fish and Wildlife Restoration Act FY 2026
Fish and Wildlife Service- Award range
- $2K – $500K
- Closes
- Oct 13, 2026
- Who can apply
- State governments, County governments, City or township governments and 12 more
ForecastedALN 93.372
BRAIN Initiative: Brain-Behavior Quantification and Synchronization – Transformative Research on Behavior at the Organismal Level
National Institutes of Health- Award range
- Amount not specified
- Est. close
- Oct 13, 2026 (est.)
- Who can apply
- State governments, County governments, City or township governments and 12 more
Closes in 6 daysALN 16.320
OVC FY 2026 Enhanced Collaborative Model (ECM) Task Force to Combat Human Trafficking
Office for Victims of Crime- Award range
- Up to $1M
- Closes
- Oct 14, 2026
- Who can apply
- State governments, County governments, City or township governments and 7 more
Closes in 6 daysALN 93.394
Assay Validation of High Quality Markers for Clinical Studies in Cancer (UH3 Clinical Trials Not Allowed)
National Institutes of Health- Award range
- Up to $250K
- Closes
- Oct 14, 2026
- Who can apply
- State governments, County governments, City or township governments and 12 more
Closes in 6 daysALN 93.394
Assay Validation of High Quality Markers for Clinical Studies in Cancer (UH2/UH3 Clinical Trial Not Allowed)
National Institutes of Health- Award range
- Amount not specified
- Closes
- Oct 14, 2026
- Who can apply
- State governments, County governments, City or township governments and 12 more
Closes in 6 daysALN 93.394
Revision Applications for Validation of Biomarker Assays Developed Through NIH-Supported Research Grants (R01 Clinical Trial Not Allowed)
National Institutes of Health- Award range
- Amount not specified
- Closes
- Oct 14, 2026
- Who can apply
- State governments, County governments, City or township governments and 12 more
Closes in 6 daysALN 93.398
NCI Pathway to Independence Award for Early-Stage Postdoctoral Researchers (K99/R00 - Independent Clinical Trial Required)
National Institutes of Health- Award range
- Amount not specified
- Closes
- Oct 14, 2026
- Who can apply
- State governments, County governments, City or township governments and 12 more
Closes in 6 daysALN 93.398
NCI Pathway to Independence Award for Early-Stage Postdoctoral Researchers (K99/R00 - Independent Clinical Trial Not Allowed)
National Institutes of Health- Award range
- Amount not specified
- Closes
- Oct 14, 2026
- Who can apply
- State governments, County governments, City or township governments and 12 more
Closes in 7 daysALN 93.242
Advancing Research on Empirically-Supported Interventions for Older Adults Living with Serious Mental Illness (SMI) (R01 Clinical Trial Optional)
National Institutes of Health- Award range
- Amount not specified
- Closes
- Oct 15, 2026
- Who can apply
- State governments, County governments, City or township governments and 12 more
Closes in 7 daysALN 93.310, 93.313
Maximizing the Scientific Value of Data Generated by the Environmental influences on Child Health Outcomes (ECHO) Program: Dissertation Grant (R36 - Clinical Trial Not Allowed)
National Institutes of Health- Award range
- Amount not specified
- Closes
- Oct 15, 2026
- Who can apply
- State governments, County governments, City or township governments and 12 more
ForecastedALN 93.213
Assessing the Feasibility of Incorporating Mechanisms in Multisite Clinical Trials of Mind and Body Interventions on Whole Person Health Restoration
National Institutes of Health- Award range
- Amount not specified
- Est. close
- Oct 15, 2026 (est.)
- Who can apply
- State governments, County governments, Independent school districts and 8 more
ForecastedALN 93.846, 93.866
Ancillary Studies to Ongoing Clinical Projects (RP1 Clinical Trial Not Allowed)
National Institutes of Health- Award range
- Amount not specified
- Est. close
- Oct 15, 2026 (est.)
- Who can apply
- State governments, County governments, City or township governments and 12 more
Closes in 8 daysALN 93.067
Strengthening Ghana Health Service laboratory services, diagnostic networks, and systems for a more effective, efficient, and sustainable response to HIV, TB, and other priority health threats
Centers for Disease Control-GHC- Award range
- Amount not specified
- Closes
- Oct 16, 2026
- Who can apply
- State governments, County governments, City or township governments and 12 more
Closes in 8 daysALN 15.243
FY26 Bureau of Land Management Youth Conservation Corps - Bureau wide
Bureau of Land Management- Award range
- $30K – $220K
- Closes
- Oct 16, 2026
- Who can apply
- State governments, County governments, City or township governments and 7 more
Agencies with the most opportunities
Also open to 501(c)(3) organizations: 206 unrestricted notices
These notices do not restrict applicant type. They may still have other eligibility conditions. Search them together →
- Algebra and Number Theory — U.S. National Science Foundation
- F26AS00062: Great Lakes Fish and Wildlife Restoration Act FY 2026 — Fish and Wildlife Service
- DoW Melanoma Research Program Melanoma Academy Scholar Award — Defense Health Agency Contracting Activity - DHACA
- DoW Melanoma Research Program Survivorship Research Award — Defense Health Agency Contracting Activity - DHACA
- DoW Melanoma Research Program Team Science Award — Defense Health Agency Contracting Activity - DHACA
- DoW Melanoma Research Program Focused Program Award – Rare Melanomas — Defense Health Agency Contracting Activity - DHACA
Before you apply
- Have your IRS determination letter ready; many agencies ask for it during application or before award.
- Colleges and universities are listed as a separate applicant type even when they are tax-exempt.
Frequently asked questions
How many federal grants are available for 501(c)(3) organizations right now?
As of the latest refresh, 425 opportunities are open for applications and 436 more are forecasted on Grants.gov. 59 of the open opportunities close within 30 days.
Which federal agencies offer the most opportunities for 501(c)(3) organizations?
Currently: Department of Health and Human Services (774), Department of Justice (15), Department of State (13), Department of Commerce (13), Department of Agriculture (9).
Are these all grants?
Not all. Federal funding notices can be grants, cooperative agreements (grants with substantial agency involvement) or other instruments. Among current opportunities for 501(c)(3) organizations: 527 grants, 352 cooperative agreements, 8 others, 1 procurement contract.
Does appearing on this list mean a 501(c)(3) organization qualifies?
No. These notices list 501(c)(3) organizations among the eligible applicant types, but each opportunity can add other requirements — location, size, matching funds, prior registration or program-specific criteria. Review the official notice before applying.
Methodology: This page lists Grants.gov opportunities whose official notice includes the applicant type “Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education”. Notices marked “Unrestricted” are open to any entity type and are shown separately below. Appearing on this page does not mean an organization is eligible; review each official notice. See how GrantsJunction sources and labels data.