Small Business Transition Grant for New Entrepreneurs (Parent R41/R42 Clinical Trial Optional)
National Institutes of Health · Department of Health and Human Services
At a glance
Small Business Transition Grant for New Entrepreneurs (Parent R41/R42 Clinical Trial Optional) is a forecasted federal grant opportunity from the National Institutes of Health (Department of Health and Human Services). The agency's forecast estimates an application due date of January 5, 2027; forecast dates can change. Applicant types listed as eligible include small businesses. Cost sharing is not required. It is funded under Assistance Listing 93.113 (Environmental Health) and 19 other listings.
Summary assembled from the official notice's fields. The official notice governs.
Key facts
- Posted
- May 27, 2026
- Est. close date
- Jan 5, 2027
- Est. award date
- Jun 1, 2027
- Award floor
- Not specified
- Award ceiling
- Not specified
- Est. total funding
- Not specified
- Expected awards
- Not specified
- Cost sharing
- Not required
- Funding instrument
- Grant
- Opportunity category
- Discretionary
- Fiscal year
- FY2027
Who can apply
- Small businesses
Additional information on eligibility (from the notice)
Only United States small business concerns (SBCs), as defined by the Small Business Administration (SBA)(sbir.gov/apply) are eligible to submit applications for this opportunity. Individuals are eligible to serve as the PD/PI if they have never been an independent PD/PI on an NIH or CDC research, or corresponding non-NIH peer-reviewed research grant, and are a U.S. Citizen or Lawful Permanent Resident.
Based on the published notice. Review the official notice for complete eligibility requirements.
What it funds
Official synopsis as published by the agency, formatted for readability.
The National Institutes of Health (NIH), including the participating Institutes, Centers and Offices, intends to publish a Notice of Funding Opportunity (NOFO) to invite eligible United States small business concerns (SBCs) to submit Small Business Technology Transfer (STTR) Phase I, and Fast-Track grant applications for the Small Business Transition Grant. Through this NOFO, NIH will support early-career scientists transitioning to entrepreneurship. In addition to funding research and development efforts at the SBC, a major component of this NOFO is entrepreneurial training, mentoring, and career development of the PD/PI.
Applications are not being solicited at this time. Notice is being provided to allow potential applicants sufficient time to develop responsive projects, including identification of complementary industry mentors and career development resources. This NOFO will utilize the R41/R42 activity code. United States small businesses that have the research capabilities and technological expertise to contribute to the R&D mission(s) of the NIH awarding components identified in this NOFO are encouraged to begin to consider applying for this new NOFO. This opportunity is available to first-time Principal Investigators, and key personnel must include a mentor with measurable effort committed to the project.
Assistance Listings
What is an ALN?- 93.113Environmental HealthProgram →
- 93.121Oral Diseases and Disorders ResearchProgram →
- 93.172Human Genome ResearchProgram →
- 93.173Research Related to Deafness and Communication DisordersProgram →
- 93.213Research and Training in Complementary and Integrative HealthProgram →
- 93.233National Center on Sleep Disorders ResearchProgram →
- 93.273Alcohol Research ProgramsProgram →
- 93.279Drug Use and Addiction Research ProgramsProgram →
- 93.350National Center for Advancing Translational SciencesProgram →
- 93.361Nursing ResearchProgram →
- 93.837Cardiovascular Diseases ResearchProgram →
- 93.838Lung Diseases ResearchProgram →
- 93.839Blood Diseases and Resources ResearchProgram →
- 93.840Translation and Implementation Science Research for Heart, Lung, Blood Diseases, and Sleep DisordersProgram →
- 93.846Arthritis, Musculoskeletal and Skin Diseases ResearchProgram →
- 93.859Biomedical Research and Research TrainingProgram →
- 93.865Child Health and Human Development Extramural ResearchProgram →
- 93.866Aging ResearchProgram →
- 93.867Vision ResearchProgram →
- 93.879Medical Library AssistanceProgram →
Reported obligations under ALN 93.113
Historical data · not a predictionAgency contact (as published)
NIH SEED (Small business Education and Entrepreneurial Development) Office of Extramural Research (OER)
SEEDinfo@nih.gov
301-827-8595
Quick answers
Is this opportunity open for applications yet?
Not yet. It is a forecast — an agency's advance notice of an expected opportunity. The agency estimates posting the full notice around November 5, 2026. Forecast details and dates can change.
Who is eligible to apply for this opportunity?
The official notice lists these applicant types as eligible: Small businesses. Additional restrictions may apply; review the full notice.
How do I apply for this opportunity?
Applications are submitted through the official source, not through GrantsJunction. Open the official notice on Grants.gov (opportunity PAR-27-040), and review the full announcement and application package. Organizations applying through Grants.gov generally need an active SAM.gov registration and a Grants.gov account, which can take several weeks to set up.
Related open opportunities
Matched on shared Assistance Listings, agency, categories and eligible applicant types.
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